"I survived organic - but to be honest I learned very little"
08.03.2026 13:22
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"I survived organic - but to be honest I learned very little"
I'm too bored of this to try and be clever about it anymore.
If you think that two men kissing, or two women kissing, requires any more explanation than a man kissing a woman, that is homophobia.
Totally agree! I see increasing SI size as a symptom of problematic shifts in publishing norms in the last few decades. Emphasis on chasing impact factors & novelty/splash means every paper has to be a bigger & bigger story, and there's disincentive to space out the content
Donโt hide the good stuff in the SI
In 2008, we published a paper on parameterizing force fields for unfolded proteins using NMR data, developing an early HPS model for intrinsically disordered proteins. The paper showed the idea, validation with synthetic data, and applications to real proteins.
Relatedly, I hate that citation conventions don't let you refer to specific parts of a reference - SI vs text, specific figures, specific sections, or even direct quotes. Makes it hard to GET material from the SI noticed later on
Whether any one individual follows it or not, the trend toward massive multi-paper-in-one papers (1 in the main text and 2-3 more in the SI) makes it harder to get smaller contributions recognized appropriately
Totally agree! I see increasing SI size as a symptom of problematic shifts in publishing norms in the last few decades. Emphasis on chasing impact factors & novelty/splash means every paper has to be a bigger & bigger story, and there's disincentive to space out the content
Another really interesting #SciHis Story by @asimovpress.bsky.social.
Goes to show that there are interesting and curious stories and facts in everything - even little things like Agar that seem simple and straightforward.
www.asimov.press/p/agar
#ScienceHistory #MolecularBiology #Agarose #Seaweed
Screenshot show 6 plasmid maps, 2 of them are flagged mismatch, while the rest of the 4 are marked as perfect match.
New interface of plasmidsaurus has been making my life easier.
My hope is that the difficulty and timeline can be reduced with tools...! One of the goals of CloneCoordinate.org is to accumulate individual expertise and let it be accessed by others
New version of our preprint on bioRxiv about bioRxiv up. Now thatโs what I call a revision โ 6 years after the first version!
It has new data about our progress and highlights from a massive user survey. 1/n
www.biorxiv.org/content/10.1...
1. Kevin Gross and I have a new paper out today PLOS Biology.
We used economic models based around screening games and the market for unpaid labor to highlight a meltdown cycle threatening peer review.
What problem do you hope bioengineering or synthetic biology approaches will enable us to tackle in the next decade?
doi.org/10.1016/j.ce...
A week ago, we had an open conversation amongst senior academics in leadership roles and their use of LLMs (in both their leadership capacities and individually). Small group, not representative, but it already taught me a great deal about the diversity of perspectives (& their consequences). 1/
๐งฌPlasmids are the workhorses of molecular biology, but are we really choosing them wisely? @vdlorenzo.bsky.social and Esteban Martรญnez-Garcรญa revisit what really defines plasmid performance and why modular standards like #SEVA matter for the future of #SynBio ๐https://doi.org/10.1111/1751-7915.70273
Bilbo looking at his phone top on bottom is ChatGPT After all, why not? Why shouldn't I keep it? You're absolutely right โ you found it, it's been with you a long while, and it's only natural to feel fond of something that's served you so well, especially when someone like Gandalf suddenly seems to want it for himself.
@loresjoberg.bsky.social
I wrote a guide on constructive peer review. This is a polished version of an internal guide I had for my group. Of course, constructive feedback is welcome, peers!
deboer.bme.ubc.ca/2025/12/09/g...
SNL should do a skit that's the 2024 presidential debate but Trump says all the things he was actually going to do
"I have... concepts of a plan. And here's where the plan begins: GREENLAND."
Great story from @chemscrapes.bsky.social on the origin of the (in)famous Samuel L. Jackson meme
What's larger, a protein or its templating mRNA ?
> The mRNA is much larger.
โฌ ๐ ๐ฌ๐๐ง๐ฌ๐ ๐จ๐ ๐ฌ๐๐๐ฅ๐ -- ๐ช๐ฎ๐๐ง๐ญ๐ข๐ญ๐๐ญ๐ข๐ฏ๐ ๐ข๐ง๐ญ๐ฎ๐ข๐ญ๐ข๐จ๐ง & ๐๐จ๐ง๐ฌ๐ญ๐ซ๐๐ข๐ง๐ญ๐ฌ -- ๐ข๐ฌ ๐ ๐ฉ๐จ๐ฐ๐๐ซ๐๐ฎ๐ฅ ๐๐ง๐๐๐ฅ๐๐ซ ๐จ๐ ๐ซ๐๐ฌ๐๐๐ซ๐๐ก.
The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...
NSF needs to hear from you. Among other points, I suggested: keep politics out of science; stop using the threat of cancelling scientific grants to try to control universities; increase NSF funding for fundamental research. Pls send around. Deadline is January 27. Thanks
www.nsf.gov/od/updates/n...
Only 0.02% but still
Looks like it's already a little larger than expected, so definitely keep an eye on that
...times a million
Adulthood is finding a piece of plastic that fell off your windshield wiper, carrying it around in your coat pocket for a month, and then finally remembering to put it back on
Creating bacterial genomic diversity through large-scale reconfigurations reveals phenotype robustness to organizational genome change https://www.biorxiv.org/content/10.64898/2026.01.06.698047v1
I hear you but may I put in a good word for Steven Universe?
I agree, and I also think it's bad even if the target of the joke is otherwise privileged and/or morally repugnant - what's your feeling there?
