Vivien Horvath

The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements - Nature Genetics This Perspective explores the co-evolution of transposable elements and KRAB zinc-finger proteins in relation to their integration into human gene regulatory networks, highlighting their potential eff...

Find our latest Perspective article in Nature Genetics on "The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements" at www.nature.com/articles/s41..., with implications for the future of research on the cause of human disease.

Wow, big time preprint drop from @jacobsenucla.bsky.social lab! One of the holy grails of DNA methylation research. Also, the 2-figure paper reminds me of the classic Science Brevia from Simon Chan and Steve showing RNA-directed DNA methylation drives de novo DNAme www.biorxiv.org/content/10.6...

📣 A fantastic resource for the study of population genomics of transposable elements. Congratulations to all @johannconfais.bsky.social ! Also very happy to see the Brachypodium resource being used for this purpose!
It's 🌈🌈 again! #TEsky #goBrachy

Very happy that i had the chance to contribute to this great study now out in NAR! 🌟🧠🧬 Check it out 👇

🎉 After a very long one (appropriately…), I’m excited to share work revealing an unexpected role for the epigenetic regulator ZFP57 - linking development, lactation, milk composition and lifelong health.

Check it out: www.nature.com/articles/s41...
#MammaryGlandBiology #DOHaD

New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488 We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

🗓️ 23-26 June 2026 🇸🇪
#PALS #summerschool in #OMICS is back!
Soon registration and info about speakers for the 3rd edition!

Organized by @claudiocantu81.bsky.social and me, @remeseiro-lab.bsky.social, with the support from @scilifelab.se and @kawresearch.bsky.social

Project Assistant The Department of Medical and Translational Biology at the Faculty of Medicine is now seeking a project assistant for a research project related to human brain aging. The position is full-time and lim

📣We are looking for a Project Assistant to join my group at the Wallenberg Center for Molecular Medicine at Umeå University. Join us if you are interested in transposable elements, epigenetics and human brain aging. 🧠🧬 Dont hesitate to reach out with any questions! 📣
umu.varbi.com/en/what:job/...

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine

We are looking for a Postdoc to join us at the Center for Gene Expression @cgen2025.bsky.social at the University of Copenhagen! Full advertisement here: employment.ku.dk/faculty/?sho...

Postdoctoral Researcher in "Cancer Neuroscience: the impact of neural activity on 3D genome organization and cellular plasticity in glioblastoma”

Excited to share I’ve received a #SSMF #Consolidator grant!

📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics

🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM

Interested? Apply now 👇
rb.gy/m7xz7b

#EMBOMobileGenome Session 4: Physiological impact 🧬 chaired by Josefa González

➡️ 'Transposon-mediated evolution of human immune gene regulation' AKA Stranger Genes 👁️🔦
presented by Edward Chuong (University of Colorado Boulder, USA) @edchuong.bsky.social @colorado.edu @gonzalezlabbcn.bsky.social

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochromati...

Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3.

www.biorxiv.org/content/10.1...

Thanks!!😊

🧠 🌟 Im very happy and grateful for receiving the Starting Grant from the Swedish Research Council. This support will allow my lab at Umeå University to further understand the role of transposons in oligodendrocyte specific human brain ageing. Looking forward to the exciting research! 🧬 🧠

Thank you! 😊

Thank you Geoff!

Thank you! ☺️

Thank you Pepi! See you soon in Heidelberg! ☺️

Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements | PNAS The origins of CpG islands (CGIs) are not known. They are relatively short GC-rich regions of DNA with a higher-than-expected occurrence of CpG din...

'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...

I’m very grateful to everyone who supported me along the way, especially my PhD and postdoc mentors (@Josefa Gonzalez @gonzalezlabbcn.bsky.social and Johan Jakobsson @jakobssonlab.bsky.social )!

I will be recruiting soon at all levels, so if you are interested, please don’t hesitate to reach out!

🌟Im happy to share that this winter I'll be starting my lab at the Wallenberg Center for Molecular Medicine at Umeå University! Excited to join the Department of Medical and Translational Biology as a Wallenberg Fellow and looking forward to new collaborations and cool transposon research 🤩 🧬

📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607

Very happy that I had the chance to contribute to this amazing work describing the role of transposable elements in Parkinson’s Disease. 🧠🧬

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics Muralidharan and colleagues develop cell-type-specific transcriptomic aging clocks using single-nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict ....

New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.

doi.org/10.1002/advs...

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

www.stemcellcenter.lu.se/article/why-...

Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5