Mark Fortner

Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve communication & collaboration.

bit.ly/4aKsNlJ

#Biotech #DrugDiscovery #AI #ProteinProd #Chemistry #AssayMgmt #Reg #Inventory

AI State of Play 2025 The AI State of Play 2025 highlights a watershed year where AI-discovered molecules achieved Phase I clinical success rates of 80-90%, significantly outperforming the historical average of 40-65%. The report identifies five structural pillars: Big Pharma "AI Factories": Companies like Eli Lilly and Pfizer are building massive internal computational infrastructures and reducing discovery timelines for small molecules to just 30 days. TechBio Maturity: Companies like Insilico Medicine achieved a "Penicillin Moment" with positive Phase 2a results for the first entirely AI-native drug. Democratized Modeling: Open-source tools like Boltz-2 and OpenFold3 have commoditized high-accuracy molecular modeling. The "Agentic" Shift: A move toward autonomous systems that can independently formulate hypotheses and execute experiments. Regulatory Adaptation: Increased focus on biologics (13-year protection) over small molecules (9-year protection) due to the Inflation Reduction Act (IRA). Download the AI State of Play 2025 to learn more: https://drive.google.com/file/d/1a6etlnbgWyC2PbZIZGGXWLCJ-saA4BSO/view?usp=drive_link

The 2025 AI State of Play is here. 🧬 AI-native drugs are hitting 80-90% Phase I success rates, fundamentally challenging Eroom's Law. This short video explainer fills in the details.

youtu.be/4BDoeGxy_ns

#AI #DrugDiscovery

The Artist Project: Kehinde Wiley YouTube video by The Met

An interesting short video on the artist Kehinde Wiley talking about John Singer Sargent. It's always interesting to see one artist dissect another's work.
youtu.be/4rvvJ0tKvmY?...

State of Play 2025 What does the "State of Play" look like for the biotech and pharma industry in 2025? In this explainer, we take a look at some of the changes over the last year—from a resurgence in funding for high-value assets to the incredible speed of AI-driven drug discovery (did you know Pfizer is hitting 30-day discovery cycles?). For more details, read our free State of Play 2025 whitepaper. https://drive.google.com/file/d/1E1y6RRas74I2a4A1lFhZwZE2F9sDQucH/view?usp=drive_link

The biotech industry entered a phase of "disciplined resilience" in 2025. While venture funding is rebounding—surging 70% in Q3 alone—the capital is being tethered to clinical validation like never before.

This explainer gives you all of the highlights.
bit.ly/3NfNn59

For readers interested in drug repurposing, this review summarizes the approaches, evaluates available in silico resources and presents case studies
www.nature.com/articles/s41...
rdcu.be/e60em

Cell and Gene Day 2026 Cell and gene therapy has some wind beneath its sails. New regulatory frameworks from the Food and Drug Administration could help streamline development and manufacturing. Large pharma companies are i...

Today at 11 AM ET: The FDA is streamlining CGT R&D and big pharma is back at the table, but can the new science, regulatory and manufacturing leaps address the fundamental issues that still haunt the field? Find out what’s actually different this time — join us.

How worried should you be about microplastics? Microplastics have been found accumulating everywhere from our water to our body tissues, but many of the claims have come under fresh scrutiny. Chelsea Whyte cuts through the research to tell you whether you really need to worry

Microplastics have been found accumulating everywhere from our water to our body tissues, but many of the claims have come under fresh scrutiny. Chelsea Whyte cuts through the research to tell you whether you really need to worry

The Digital Transformation Roadmap - Improving Capital Efficiency & Velocity in Drug Discovery A Digital Transformation Roadmap can show you how to apply technologies like AI, automation and advanced analytics to improve the efficiency and velocity of your drug discovery operations. In this video, we take a look at some of the ways that these technologies can be applied to transform the way new medicines are discovered, and how a roadmap can help provide you with a plan for getting there. #digitaltransformation #drugdiscovery #ai #automation #analytics

Give us 10 minutes and we'll show you how Digital Transformation with AI and Automation can change your drug discovery operations.

bit.ly/4blEtN6

#DrugDiscovery #DigitalTransformation #AI #automation.

Creating medicine has the complexity of a moonshot. In the lab, it’s a journey of a million data points. 🚀🧬

Pipeline is your Mission Control for:
🔹 Target selection
🔹 Library design
🔹 Project planning
🔹 Assay Management
🔹 CRO/CDMO collab

pipeline@aspen.bio

#Biotech #DrugDiscovery

Lafayette father first in Colorado to receive newly approved pancreatic cancer drug A Lafayette father's battle with stage 4 pancreatic cancer is taking a hopeful turn as he becomes the first in Colorado to receive a newly approved targeted therapy.

Lafayette father first in Colorado to receive newly approved pancreatic cancer drug | #cancer #PancreaticCancer

Scientists find the genetic switch that makes pancreatic cancer resist chemotherapy Scientists have identified a crucial molecular switch that decides whether pancreatic cancer cells resist chemotherapy or respond to it. The key player, a gene called GATA6, keeps tumours in a more st...

Scientists find the genetic switch that makes pancreatic cancer resist chemotherapy | #cancer #PancreaticCancer

In reversal, Prime Medicine will seek FDA approval of previously shelved gene therapy While other drugmakers have criticized the FDA’s recent judgment on rare disease treatments, Prime Medicine says the agency’s rhetoric pushed it to move forward with a rare immune disease therapy it h...

In a reversal, Prime Medicine will seek FDA accelerated approval for a previously shelved gene editing therapy in rare immune disease, citing the agency’s evolving stance on rare conditions.

This is why red states have higher voter apathy. Always shenanigans.

I feel bad for these folks just trying to exercise their constitutional right to vote and having to deal with this mess.

Info in 🧵

Theravance ends R&D, lays off half of workforce after repeated Phase 3 fails Theravance Biopharma will wind down its entire R&D organization and lay off 50% of its overall workforce after another Phase 3 fail for an experimental medicine called ampreloxetine.

Theravance is shutting down R&D and cutting half its workforce after yet another Phase 3 failure for ampreloxetine, as the biotech weighs strategic alternatives.

DURBIN: How does taking dad from child dying of cancer qualify as a violent crime?

NOEM: I don't know what you're speaking of

D: Ruben Torres 2 weeks ago buried his daughter. When he was arrested at Home Depot, he said, 'Please. My daughter is dying.' They deported him. Was he a violent criminal?

wow -- Tillis goes ballistic on Noem, telling her "what we've seen is a disaster under your leadership"

AI State of Play 2025 The AI State of Play 2025 highlights a watershed year where AI-discovered molecules achieved Phase I clinical success rates of 80-90%, significantly outperforming the historical average of 40-65%. The report identifies five structural pillars: Big Pharma "AI Factories": Companies like Eli Lilly and Pfizer are building massive internal computational infrastructures and reducing discovery timelines for small molecules to just 30 days. TechBio Maturity: Companies like Insilico Medicine achieved a "Penicillin Moment" with positive Phase 2a results for the first entirely AI-native drug. Democratized Modeling: Open-source tools like Boltz-2 and OpenFold3 have commoditized high-accuracy molecular modeling. The "Agentic" Shift: A move toward autonomous systems that can independently formulate hypotheses and execute experiments. Regulatory Adaptation: Increased focus on biologics (13-year protection) over small molecules (9-year protection) due to the Inflation Reduction Act (IRA). Download the AI State of Play 2025 to learn more: https://drive.google.com/file/d/1a6etlnbgWyC2PbZIZGGXWLCJ-saA4BSO/view?usp=drive_link

The 2025 AI State of Play is here. 🧬 AI-native drugs are hitting 80-90% Phase I success rates, fundamentally challenging Eroom's Law. This short video explainer fills in the details.

youtu.be/4BDoeGxy_ns

#AI #DrugDiscovery

Got 8 minutes? Let us show you how the Pipeline Drug Discovery platform can transform your research operations, reduce risk & costs, and improve communication & collaboration.

bit.ly/4aKsNlJ

#Biotech #DrugDiscovery #AI #ProteinProd #Chemistry #AssayMgmt #Reg #Inventory

If the pandemic taught us anything, it’s that we can do six impossible things before breakfast. It requires more than just great science though —it requires a better platform.

Streamline your R&D operations with Pipeline.

bit.ly/3MDFuGU

#DrugDiscovery #Biotech #AI

FDA is ‘not convinced’ UniQure’s Huntington’s therapy has benefit, senior official says The FDA believes that an experimental therapy for Huntington’s disease from UniQure wasn't providing benefit for patients, a senior official told STAT.

The FDA has concluded that an experimental treatment for Huntington’s disease developed by UniQure was not providing benefit for patients based on existing clinical data. www.statnews.com/2026/03/03/u...

Rijksmuseum reveals painting to be early work by Rembrandt 17th-century Dutch master’s Vision of Zacharias in the Temple to go on display this week

Rijksmuseum reveals painting to be early work by Rembrandt | #art #Rembrandt

Candid to go public via reverse merger with Rallybio Candid Therapeutics will go public through a reverse merger as it seeks to prove whether T cell engagers can shake up the treatment of autoimmune diseases.

Candid will go public through a reverse merger with Rallybio.
endpoints.news/candid-to-go...

Low tide beach at dusk with rippled wet sand in the foreground reflecting blue and gold light. A long wooden pier stretches across the horizon with small lights glowing along its length. Waves break beneath the pier, and a few distant surfers appear as silhouettes near the right side of the frame under a sky that shifts from deep blue to warm yellow.

Sunset at Crystal Pier. Pacific Beach, San Diego, California

#SanDiego #sunset #PacificBeach #CrystalPier

A titan of vaccine development sees his field’s achievements slip away Stanley Plotkin, the 93-year-old "godfather of vaccines," is watching his field’s achievements slip away.

“In a pair of recent interviews with STAT, Plotkin expressed dismay at seeing the achievements of his career & his field slip away. He knows what lies ahead…
“All I can say is that I’m beginning to regret having lived so long —because we’re going downhill,” Plotkin said” @jackiantonovich.bsky.social

State of Play 2025 What does the "State of Play" look like for the biotech and pharma industry in 2025? In this explainer, we take a look at some of the changes over the last year—from a resurgence in funding for high-value assets to the incredible speed of AI-driven drug discovery (did you know Pfizer is hitting 30-day discovery cycles?). For more details, read our free State of Play 2025 whitepaper. https://drive.google.com/file/d/1E1y6RRas74I2a4A1lFhZwZE2F9sDQucH/view?usp=drive_link

The biotech industry entered a phase of "disciplined resilience" in 2025. While venture funding is rebounding—surging 70% in Q3 alone—the capital is being tethered to clinical validation like never before.

This explainer gives you all of the highlights.
bit.ly/3NfNn59

Creating medicine has the complexity of a moonshot. In the lab, it’s a journey of a million data points. 🚀🧬

Pipeline is your Mission Control for:
🔹 Target selection
🔹 Library design
🔹 Project planning
🔹 Assay Management
🔹 CRO/CDMO collab

pipeline@aspen.bio

#Biotech #DrugDiscovery

New iron nanomaterial wipes out cancer cells without harming healthy tissue Scientists at Oregon State University have engineered a powerful new nanomaterial that zeroes in on cancer cells and destroys them from the inside out. Designed to exploit cancer’s unique chemistry—it...

New iron nano material wipes out #cancer cells without harming healthy tissue

Merck to wind down Gardasil production at N.C. plant, lay off 150-plus Facing vaccine pressures in multiple markets, Merck & Co. is pruning the ranks at one of its key U.S. production facilities.  | In a Worker Adjustment and Retraining Notification Act alert filed this ...

Merck, working through Gardasil demand woes, cuts jobs in N.C.

Hidden Virus Found in Gut Bacteria Is Linked to Colorectal Cancer Researchers have made a significant step forward in understanding how gut bacteria, and specifically a newly discovered virus, can contribute to colorectal cancer – one of the most common forms of can...

Hidden Virus Found in Gut Bacteria is Linked to Colorectal Cancer | #cancer #CRC

Targeting adhesion GPCRs

The therapeutic potential of orphan adhesion G-protein-coupled receptors
www.nature.com/articles/s41...
rdcu.be/e52UX

This new Review discusses opportunities to target aGPCRs in cancer, psychiatric disorders and autoimmune diseases, based on advances in structural biology