Schuller Jan

Thrilled to be able to finally post my first adventure into secondary metabolism!:

Flavoaffinins, Elusive Cellulose-Binding Natural Products from an Anaerobic Bacterium

pubs.acs.org/doi/full/10....

Co-authors: Ruocheng Yu, f. undergrad Jessie Lee, @katherinem.bsky.social , and Emily Balskus!

Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓

Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!

The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...

📢 Postdoc position: Cell Biology of Cyanobacteria

in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.

More information at shorturl.at/wNnDT (see Project 2)

🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025

Please repost. #Postdoc

Congratulations Johannes. A milestone work! Thanks for including us in this exciting project. We are always happy to assist! What a beautiful structure and amazing evolutionary implications.

Really looking forward to it. It's a great opportunity to meet friends and make new ones. We are also excited to present our latest structural work on the methyl branch of methanogens. Unpublished and highly exciting!

Emergence of fractal geometries in the evolution of a metabolic enzyme - Nature Citrate synthase from the cyanobacterium Synechococcus elongatus is shown to self-assemble into Sierpiński triangles, a finding that opens up the possibility that other naturally occurring molecular-scale fractals exist.

www.nature.com/articles/s41...
By any chance??? It is a cyanobacteria right?

Origin of chaperone dependence and assembly complexity in Rubisco biogenesis Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...

A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...

Oh wow, let's hope with our new discoveries we don't outdate it too fast ;)

Die aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼‍🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung!
@synmikro.bsky.social @loewe-tree-m.bsky.social.

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...

‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...

What an amazing portrait for such an great violinist and scientist. Very well done. And very nice ending 😁 with the final in the music 🎶

He wants to reveal the secret behind the body's battery YouTube video by Wallenbergstiftelserna

Thank you Knut and Alice Wallenberg Foundation for producing this wonderful video on our research, and for the generous long-term support on our work. youtu.be/A12FvTn812Q

#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

we were already happy that these fascinating microbes were called 𝗶𝗻𝘁𝗿𝗮𝘁𝗲𝗿𝗿𝗲𝘀𝘁𝗿𝗶𝗮𝗹𝗲𝘀, but 𝗮𝗲𝗼𝗻𝗼𝗽𝗵𝗶𝗹𝗲𝘀 sounds definitively more, well... scientific (😎)
#MicroSky

This method is an absolute game changer 🔥 when applied to bioenergetic problems. You should have a read. Wait for it 😶‍🌫️ great things are coming!!!

Amazing paper, the best of two worlds- combination of high resolution cryoEM and small proteins - posttranslational Regulation of the core bioenergetic machinery of methanogenesis by a small protein! Well done Tristan and Eva!!👍🥂🥂 @schullerjm.bsky and @Schmitz-Streit lab - possible through @dfg.de

This work is a cornerstone in a long-term effort of the lab to understand the pumps of life. I call it a "Tripple in Bioenergetics" now.

The small protein MtrI blocks the Na+ binding subunit MtrCDE, bascially forming a plug for the channel. This could be important to prevent sodium leakage, when the complex gets damaged by oxygen.

The structure has also something for resolution fans! Such a nice coordinated sodium ion 😅

Tristan could show this by pull-down experiments. Irrespective of the growth condition, the oxygen sensitive behaviour was present.

This is a showcase study how small ORF proteins can regulate a central bioenergetic machinery. MtrI, binds here in a oxygen sensitive manner to the methyltransferase shuttle domain of MtrA.

Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .

www.biorxiv.org/content/10.1101/2025.06.02.657420v1

Our structural core gene pipeline Unicode is now published at GBE
📄 doi.org/10.1093/gbe/...

Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...

Amazing paper, putting the spotlight on small proteins as modulators of the core bioenergetic machinery of methanogenesis.

Small ORF16 modulates the Mtr complex activity in Methanosarcina mazei Gö1 depending on the molecular hydrogen availability Small open reading frame (small ORF)-encoded proteins, with less than 100 amino acids in length, have attracted increasing attention over the past decade after being largely overlooked due to limitati...

Check out our latest preprint on small proteins with big impact: MtrR fine-tunes energy metabolism in M.mazei by modulating the Mtr complex in response to H₂. Great work of Tim Habenicht + @SPP2002 collegues + @schullerjm.bsky.social - congrats TIM, 2. step to PhD!
www.biorxiv.org/content/10.1...

Comic. PERSON: It’s weird how, despite being one of the main branches of the tree of life, no archaea species are known to cause disease in humans. PERSON WITH SHORT HAIR: Personally, I think it’s because those gross methane breathers are too weird and incompetent to figure out how to hurt us even if they wanted to. [from small point under microscope on desk]: *Hey!* [caption] Bad news: After overhearing a conversation in our lab, Archaea has finally started harming humans.

Archaea

xkcd.com/3095/

This is so cool 😎 congratulations 🎉 amazing work.

Does he believe in 0.143, 0.3 or 0.5 as the correct cutoff?