Nicolas Dumont

New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target Cellular senescence accumulates in the skeletal muscle of patients with myotonic dystrophy Type 1, leading to the production of senescence-associated secretory phenotype (SASP) factors that have detr...

I’m happy to share this perspective paper regarding senescence and senotherapeutics in myotonic dystrophy. Great work led by Cécilia Légaré in collaboration with Elise Duchesne and ⁦‪Andy Berglund labs. Very nice experience to work with these DM1 experts.

onlinelibrary.wiley.com/doi/10.1002/...

Transcriptomic and lipidomic profiling reveals distinct bioactive lipid signatures in slow and fast muscles and highlights the role of resolvin‐D2 in fiber type determination during myogenesis Transcriptomics (bulk and single-nuclei RNAseq) and lipidomics (mass spectrometry) analysis showed that slow-twitch muscle (soleus) is enriched in bioactive lipids derived from docosahexaenoic acid (...

I’m pleased to share our recent work, led by Lupann Rieger during her Master’s thesis, which has been published in ⁦FASEB J‬⁩. We provide new insights regarding how bioactive lipids regulate fiber typing.

faseb.onlinelibrary.wiley.com/doi/10.1096/...