Iván Darío Bravo Tobar. M.D. | M.Sc. | Ph.D.

Toward a Disease-Modifying Therapy for Dravet Syndrome | NEJM The authors describe the scientific foundations of a study of zorevunersen, an antisense oligonucleotide, for the treatment of a severe epilepsy syndrome.

Toward a Disease-Modifying Therapy for Dravet Syndrome | New England Journal of Medicine www.nejm.org/doi/full/10....

Clinical Neuroinflammatory Mimics of Multiple Sclerosis Clinical Neuroinflammatory Mimics of Multiple Sclerosis

practicalneurology.com/diseases-dia...

Weight stigma in Latin America and the Caribbean: regional evidence and a call to action by ABESO Weight stigma (WS) negatively impacts the health and well-being of people living with obesity (PwO). However, it remains understudied in Latin America and the Caribbean. This review synthesizes findin...

Weight stigma in Latin America and the Caribbean: regional evidence and a call to action by ABESO - The Lancet Regional Health – Americas www.thelancet.com/journals/lan...

YMN-V115: a novel humanized BCMA/GPRC5D/CD3 trispecific antibody in relapsed/refractory multiple myeloma Background Multiple myeloma (MM) is a hematologic malignancy characterized by a high relapse rate despite recent therapeutic advances. B-cell maturation antigen (BCMA) and G protein-coupled receptor c...

jitc.bmj.com/content/14/2...

Sleep apnea, heart health and testosterone: unravelling the triad of well-being Sleep disorders, cardiovascular diseases (CVDs), and hormonal imbalances, particularly with respect to testosterone levels, are closely interconnected and significantly impact public health. This revi...

Sleep apnea, heart health and testosterone: unravelling the triad of well-being - eBioMedicine www.thelancet.com/journals/ebi...

Minimally invasive surgical resection reduces one-year mortality, especially in high-risk colon cancer patients: an emulated trial The emulated trial confirms that MIS resection for colon cancer reduces mortality at one year, compared with OS resection. However, patients in higher-risk groups, who were most likely to benefit from...

Minimally invasive surgical resection reduces one-year mortality, especially in high-risk colon cancer patients: an emulated trial - eClinicalMedicine www.thelancet.com/journals/ecl...

Do quasars form from primordial black holes? Abstract. We explore the consequences of a novel but increasingly well-supported hypothesis that supermassive black holes may have formed from primordial b

Do quasars form from primordial black holes? url: academic.oup.com/mnras/articl...

Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study AbstractAims. As ‘one-size-fits-all’ physical activity (PA) recommendations are increasingly challenged, the optimal PA patterns across different predicted

Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study url: academic.oup.com/eurjpc/artic...

Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline This longitudinal study uses data from 1 clinical trial and 4 observational studies to investigate whether sex and aggregated Aβ synergistically predict levels of plasma p-tau217 and whether p-tau217 ...

Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline url: jamanetwork.com/journals/jam...

HEARTS quality: a policy framework to strengthen hypertension and cardiovascular risk management in primary healthcare—insights from HEARTS in the Americas HEARTS in the Americas is the largest-scale implementation of the WHO's global initiative, with 33 countries participating, 28 having adopted standardized clinical pathways, and about 10,000 primary h...

HEARTS quality: a policy framework to strengthen hypertension and cardiovascular risk management in primary healthcare—insights from HEARTS in the Americas - The Lancet Regional Health – Americas www.thelancet.com/journals/lan...

E-cigarettes versus combination nicotine replacement therapy following a recent failed quit attempt: a pragmatic randomized trial through state tobacco quitlines Among quitline users with a recent failed quit attempt, e-cigarettes combined with quitline counseling were not more effective than combination NRT in increasing smoking abstinence after 8 weeks’ foll...

E-cigarettes versus combination nicotine replacement therapy following a recent failed quit attempt: a pragmatic randomized trial through state tobacco quitlines - The Lancet Regional Health – Americas www.thelancet.com/journals/lan...

Disappearance of a massive star in the Andromeda Galaxy due to formation of a black hole When a massive star reaches the end of its lifetime, its core collapses and releases neutrinos that drive a shock into the outer layers (the stellar envelope). A sufficiently strong shock ejects the e...

Disappearance of a massive star in the Andromeda Galaxy due to formation of a black hole | Science www.science.org/doi/10.1126/...

Candidozyma auris (formerly Candida auris): resistant, long lasting, and everywhere Invasive fungal diseases represent a significant global health concern, with Candidozyma auris (formerly Candida auris) emerging as a major healthcare…

www.sciencedirect.com/science/arti...

Glucose levels are associated with mood, but the association is mediated by ratings of metabolic state We conclude that hunger-related mood shifts depend on conscious sensing of the body's internal state instead of acting subconsciously. Our study highlights the relevance of considering the self-report...

Glucose levels are associated with mood, but the association is mediated by ratings of metabolic state - eBioMedicine www.thelancet.com/journals/ebi...

Effectiveness of a guideline implementation tool for supporting management of mental health complications after mild traumatic brain injury versus usual care in primary care: a triple-blind, cluster-r... The guideline implementation tool designed for proactive management of mental health complications after mild traumatic brain injury did not result in clinically meaningful reductions in the risk of m...

Effectiveness of a guideline implementation tool for supporting management of mental health complications after mild traumatic brain injury versus usual care in primary care: a triple-blind, cluster-randomised controlled trial - The Lancet Primary Care www.thelancet.com/journals/lan...

Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway - Scientific Reports Scientific Reports - Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway

www.nature.com/articles/s41...

Childhood Physical Fitness as a Predictor of Cognition and Mental Health in Adolescence: The PANIC Study - Sports Medicine Background Cognitive and mental health problems are highly prevalent in adolescence. While higher levels of physical fitness may mitigate these problems, there is a lack of long-term follow-up studies...

link.springer.com/article/10.1...

#mentalhealth #adolescence #cognitive

Role of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental condition characterized by persistent inattention, hyperactivity, and impulsivity. Although its precise etiology remains unclear, current evidence suggests that ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

A systematic review on type 3 diabetes: bridging the gap between metabolic dysfunction and Alzheimer’s disease - Diabetology & Metabolic Syndrome Background Alzheimer’s disease (AD) is increasingly associated with metabolic dysfunction, particularly insulin resistance, which impairs neuronal signaling and energy metabolism. Disruption of brain ...

link.springer.com/article/10.1...

Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts Common and rare genetic variation confer context-specific genetic risk in patients with IPF both competitively and cooperatively. In contrast to known IPF common risk variants, the telomere length PRS...

Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts - The Lancet Respiratory Medicine www.thelancet.com/journals/lan...

Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational st... Our findings reveal that larger stroke lesions are associated with accelerated ageing in the ipsilesional hemisphere and paradoxically decelerated brain ageing in the contralesional hemisphere, sugges...

Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study - The Lancet Digital Health www.thelancet.com/journals/lan...

Fermented Moringa oleifera leaves and Ganoderma lucidum mixtures ameliorate cognitive deficits in scopolamine-induced dementia rats by enhancing brain antioxidant and cholinergic functions Moringa oleifera Lam. (Moringaceae) and Ganoderma lucidum (Curtis) P. Karst. (Ganodermataceae) are two natural resources with established neuroprotective properties. However, whether their combinat...

Full article: Fermented Moringa oleifera leaves and Ganoderma lucidum mixtures ameliorate cognitive deficits in scopolamine-induced dementia rats by enhancing brain antioxidant and cholinergic functions www.tandfonline.com/doi/full/10....

Evaluation of thymidine kinase 1 and folate receptor alpha as potential biomarkers in prostate cancer - Scientific Reports Scientific Reports - Evaluation of thymidine kinase 1 and folate receptor alpha as potential biomarkers in prostate cancer

www.nature.com/articles/s41...

Not just a pain in the bone Growth factors secreted by sensory nerves promote fracture healing

Not just a pain in the bone | Science www.science.org/doi/10.1126/...

Little red dots as young supermassive black holes in dense ionized cocoons - Nature The highest-quality JWST spectra reveal that little red dots are young supermassive black holes shrouded in dense cocoons of ionized gas, where electron scattering, not Doppler motions, broadens ...

www.nature.com/articles/s41...

Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH Di Pastena et al. report that EVT0185, a dual ACLY/ACSS2 inhibitor, improves insulin sensitivity and steatosis while reducing fibrosis in MASH. By inhibiting acetate-driven cholesterol biosynthesis, w...

Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH: Cell Metabolism www.cell.com/cell-metabol...

Frontiers | Network pharmacology-based insights into the role of gut microbiota metabolites in insulin resistance BackgroundExtensive research has demonstrated that the gut microbiota plays a critical role in maintaining homeostasis and promoting overall human health. Ho...

www.frontiersin.org/journals/mic...

Treatment of Refractory Syndrome of Inappropriate Antidiuresis With Sodium-Glucose Cotransporter-2 Inhibitor The objective of this report is to describe a patient with syndrome of inappropriate antidiuresis (SIAD) who was successfully treated with empaglifloz…

www.sciencedirect.com/science/arti...

Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome AbstractBackground. Polycystic ovary syndrome (PCOS) is associated with adverse clinical outcomes that may differ according to PCOS phenotype.Methods. Usin

Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome url: academic.oup.com/jcem/article...

Dopamine and Mood in Psychotic Disorders This cross-sectional study uses fluorine F 18–labeled fluorodopa (18F-DOPA) positron emission tomography (PET) to test for differences in dopamine synthesis capacity between affective syndromes across...

Dopamine and Mood in Psychotic Disorders url: jamanetwork.com/journals/jam...