Deepak Saini

We are excited to share our new preprint:

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.

www.biorxiv.org/content/10.64898/2025.12.01.691499v1

differential contribution of H3K9 methyltransferases to boundaries at satellites

A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...

Great work! Definitely on my reading list!

Our #Epi2025 Trainee Session honoring the legacy of C. David Allis was an incredible success last night! Huge thank you to our selected trainees for sharing their outstanding research, and to our session chairs for organizing such a thoughtful introduction honoring Dave.

Excited to be attending the #EpiCypher2025 conference in beautiful Cancun! I’ll be giving a talk on our latest work on TRIM28, DNA methylation and p53 lineage regulation in human stem cells. Looking forward to connecting with everyone there! ☀️🧬🌴

A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...

What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...

Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells Transcriptional regulation of transposons and genes by TRIM28 and 5mC is critical for proper mammalian embryonic development, but the specific roles for these mediators in human embryonic and placenta...

New pre-print!🚨
Ever curious about TE regulation by TRIM28 in placental stem cells? Or what happens to embryonic and trophoblast stem cells when you lose DNA methylation?
We explore those questions here!
www.biorxiv.org/content/10.1...

DNA methylation influences human centromere positioning and function - Nature Genetics Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

Engulfing to Adapt: Efferocytosis by Epithelial Cells Triggers Cell State Transitions During Tissue Remodeling Hormone deprivation treatments are a leading approach in prostate cancer treatment. Following deprivation, the organ regresses from a fully differentiated secretory organ to one less than 50% of the o...

Beautiful work by Adda! Definitely worth a read!
www.biorxiv.org/content/10.1...

Looks like I got hacked on twitter, oh well nothing of value lost 🤣