Thomas P. Mathews, PhD

ELOVL6 activity attenuation induces mutant KRAS degradation - Nature Chemical Biology Inhibition of ELOVL6, a fatty acid elongation enzyme, selectively degrades mutant KRAS, disrupts its membrane localization and suppresses tumor growth, revealing a novel vulnerability in KRAS-driven c...

Great paper from Shana Kelley’s group about how the elongation of fatty acids by ELOVL6 maintains membrane anchor points that activate pathogenic KRAS variants. An unexpected way that fatty acid metabolism regulates a yet “unbridgeable” oncogenic variant. Very cool.

www.nature.com/articles/s41...