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James Ashford

@jelashford

Researcher in Machine Learning and Genetics. Here to explore projects in ALife and machine learning - particularly interested in self organising systems and interpretability! (he/him)

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Latest posts by James Ashford @jelashford

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Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data.

The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k...

Figure 1 shows they key result

06.03.2026 19:32 πŸ‘ 161 πŸ” 77 πŸ’¬ 5 πŸ“Œ 8
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Todepond dot com

new blog post

"Automatic writing"
www.todepond.com/sky/automati...

01.03.2026 00:50 πŸ‘ 13 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Hannah Spencer: the Green MP speaking to everyday people’s frustrations Winner of Gorton and Denton byelection was driven into politics by growing gap between super-rich and the β€˜rest of us’

The small, brave band of MPs who represent the trampled, not the tramplers, has a very welcome new member.

We should all ask ourselves why, in a supposed democracy, such representatives are so rare.

www.theguardian.com/politics/202...

27.02.2026 13:26 πŸ‘ 2040 πŸ” 499 πŸ’¬ 52 πŸ“Œ 16

Keir Starmer's attempt to paint the Greens as extremists yet again reveals his intolerance of political difference. His instincts are illiberal and authoritarian.

27.02.2026 19:44 πŸ‘ 1673 πŸ” 352 πŸ’¬ 101 πŸ“Œ 20

this is extremely dangerous.

27.02.2026 20:02 πŸ‘ 580 πŸ” 320 πŸ’¬ 15 πŸ“Œ 11
26.02.2026 10:43 πŸ‘ 1065 πŸ” 175 πŸ’¬ 12 πŸ“Œ 2
INTRODUCING! 

Hannah Spencer 

The new Green MP for GORTON & DENTON 

Green Party 

Promoted by Chris Williams on behalf of The Green Party, both at PO Box 78066, London SE16 9GQ

INTRODUCING! Hannah Spencer The new Green MP for GORTON & DENTON Green Party Promoted by Chris Williams on behalf of The Green Party, both at PO Box 78066, London SE16 9GQ

Introducing Hannah Spencer MP πŸ’š

27.02.2026 04:31 πŸ‘ 4457 πŸ” 1036 πŸ’¬ 183 πŸ“Œ 340

Now there is hope! It's no longer a choice between grim and grimmer. We can vote for who we want and win. Anywhere.
It's just one constituency, but the Green victory in Gorton and Denton is an electric shock to our political system.

27.02.2026 07:33 πŸ‘ 3704 πŸ” 740 πŸ’¬ 96 πŸ“Œ 41
Hannah and Zack having a selfie

Hannah and Zack having a selfie

Final weekend. One last push.

This is about whether you want local plumber Hannah Spencer or the extreme Reform candidate.

It's hope vs hate.

It's Greens vs Reform.

Hope can win.

22.02.2026 08:37 πŸ‘ 2334 πŸ” 639 πŸ’¬ 69 πŸ“Œ 43

I truly can’t handle reading this news about OpenAI’s disregard for public safety on the same day as I saw Sam Altman equate the energy use of AI models with the energy use of humans, reducing humanity to a resource calculation to be managed so he can pursue his AGI god.

I’m just so disgusted.

22.02.2026 02:48 πŸ‘ 340 πŸ” 90 πŸ’¬ 6 πŸ“Œ 9
aeva
@aeva@mastodon.gamedev.place

i'll say one nice thing about ai slop: the ai generated preview images continue to be a reliable indicator that there are other major issues with the article or video they represent.  if the author couldn't be bothered to try to land a solid first impression, why, you can bet they didn't care enough to try and make anything else worth your time

straw man: "but i can't draw and i hate artists"

look pal, you could take a sharpie and a piece of paper and draw crude stick figures with comic speech bubbles saying something witty and relevant to your blog post/video and I would be 10000x more impressed than the mockery of the human spirit you decided fit to represent your mingnum opus instead

aeva @aeva@mastodon.gamedev.place i'll say one nice thing about ai slop: the ai generated preview images continue to be a reliable indicator that there are other major issues with the article or video they represent. if the author couldn't be bothered to try to land a solid first impression, why, you can bet they didn't care enough to try and make anything else worth your time straw man: "but i can't draw and i hate artists" look pal, you could take a sharpie and a piece of paper and draw crude stick figures with comic speech bubbles saying something witty and relevant to your blog post/video and I would be 10000x more impressed than the mockery of the human spirit you decided fit to represent your mingnum opus instead

mastodon.gamedev.place/@aeva/116102...

21.02.2026 09:47 πŸ‘ 123 πŸ” 16 πŸ’¬ 5 πŸ“Œ 1
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1/πŸ“’ Announcing our next ERA Journal Club session

πŸ“Feb 28, 4:00 PM GMT on Discord: discord.gg/m3qvuXgkZ7

Topic: Evochora, an open-source lab for embodied digital evolution. 🧬🧱

Project: github.com/evochora/evo...
Demo: evochora.org

#ALife #Evolution #Evochora

18.02.2026 13:46 πŸ‘ 12 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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NEW REPORT – The AI climate hoax – Ketan Joshi A new report on AI greenwashing, analysing the rhetoric and evidence behind the idea big tech will solve climate change

So, @ketanjoshi.co who has been on the beat for a long time, actually looked into the story of if "AI" can "solve climate change". Conceptually as well as evidence based.

Super worth reading and sharing around.

17.02.2026 10:15 πŸ‘ 86 πŸ” 42 πŸ’¬ 3 πŸ“Œ 1
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Opinion | Something Surprising Happens When Bus Rides Are Free

There's a few likely consequences of having free buses...and they will probably surprise you! Really happy to be able to share this perspective today in the New York Times.

www.nytimes.com/2026/02/13/o...

13.02.2026 15:02 πŸ‘ 270 πŸ” 114 πŸ’¬ 10 πŸ“Œ 11
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This doesn’t bode well for the lessons

10.02.2026 16:12 πŸ‘ 226 πŸ” 26 πŸ’¬ 13 πŸ“Œ 5
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A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

13.02.2026 11:42 πŸ‘ 497 πŸ” 209 πŸ’¬ 10 πŸ“Œ 28

The genome isn't a blueprint. But what is it?

I originally imagined this as a reported feature on metaphors of the genome, but it ended up being an essay.

And at the end I share the metaphor I personally ended up landing on. If you want to tell me why it is wrong, you'll need to read the story ;)πŸ§ͺ

12.02.2026 20:56 πŸ‘ 42 πŸ” 15 πŸ’¬ 4 πŸ“Œ 2
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β€œJim Ratcliffe’s comments were outrageous. They are offensive and they were deeply wrong. We do have a problem in our country, and that problem is inequality. It’s not immigration.”

Ellie Chowns on #BBCQT, rejecting attempts to blame migrants for country's problems.

12.02.2026 22:54 πŸ‘ 873 πŸ” 264 πŸ’¬ 21 πŸ“Œ 25

Palestine Action have WON their judicial review in the High Court!
A massive victory for free speech, freedom of association and the right to protest.
A massive defeat for the draconian attempts by Keir Starmer's government to curtail our fundamental rights.

13.02.2026 10:13 πŸ‘ 2804 πŸ” 820 πŸ’¬ 58 πŸ“Œ 51
Celtic-style braids fill a square, with a criss-cross pattern down the center and folds along the sides. The loops and knots are in deep purple with silver edges over a field of green and gold.

Celtic-style braids fill a square, with a criss-cross pattern down the center and folds along the sides. The loops and knots are in deep purple with silver edges over a field of green and gold.

#GenerativeArt interlude

Revival and reworking of an old project: Celtic braids

#XQuery #SVG #CreativeCoding

11.02.2026 18:36 πŸ‘ 10 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
10.02.2026 03:27 πŸ‘ 5237 πŸ” 1685 πŸ’¬ 32 πŸ“Œ 32
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What a great week at the @aliceworkshop.org (Artificial Life, Intelligence, Complexity & Evolution) in Copenhagen.

Our multidisciplinary group worked intensely for the whole week and we got the 2nd prize!!

Thanks to the amazing organizers from the REAL lab and the jury.

06.02.2026 18:11 πŸ‘ 11 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Drugs policy approach needs to change, Zack Polanski says The Green Party leader of England and Wales says there needs to be a

Drug laws have never stopped people from using drugs.

They've stopped people from using drugs safely.

It's time to legalise *and* regulate.

www.bbc.co.uk/news/article...

02.02.2026 12:06 πŸ‘ 1710 πŸ” 394 πŸ’¬ 108 πŸ“Œ 55
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Genuary 30: It’s not a bug, it’s a feature. I explored corner smoothing with superellipses and squircles. Tried to make shapes not overlap, ran into a few unexpected bugs, and guess what, sometimes they still do πŸ˜‰ #genuary #genuary30 #genuary2026

30.01.2026 08:29 πŸ‘ 9 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Help us make hope normal again.

Join the Green Party now.

22.01.2026 19:07 πŸ‘ 7004 πŸ” 2585 πŸ’¬ 204 πŸ“Œ 1044

I know we're all seeing 87 unhinged things per day, but "guys if our multi billion dollar product doesn't start being useful for something, literally anything, the people might not appreciate us wrecking the planet over it anymore" is a truly bananapants thing to say out loud

22.01.2026 06:29 πŸ‘ 5048 πŸ” 1995 πŸ’¬ 23 πŸ“Œ 6

[AI bubble bursts] billionaire tech bro: the stupid consumer did not understand it

22.01.2026 02:42 πŸ‘ 10869 πŸ” 3712 πŸ’¬ 83 πŸ“Œ 36

it's so grim. so many experienced people told them this years ago. programmers said vibe coding would create security and documentation risks. writers said editing would eat as much time as generation saved, and quality would suffer. stop? why stop when you can accelerate into the wall harder.

20.01.2026 07:28 πŸ‘ 91 πŸ” 19 πŸ’¬ 5 πŸ“Œ 1
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Amazon's Ring to partner with Flock, a network of AI cameras used by ICE, feds, and police | TechCrunch Agencies that use Flock can request that Ring doorbell users share footage to help with "evidence collection and investigative work."

It was inevitable.

19.01.2026 08:02 πŸ‘ 3608 πŸ” 2105 πŸ’¬ 41 πŸ“Œ 615
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Genuary 18: Unexpected path. A path that bends and reroutes itself across a familiar grid of pulleys. The underlying system is made visible as well to get a glimpse how the system is working. #genuary #genuary18 #genuary2026

18.01.2026 07:36 πŸ‘ 11 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0