Dr Victor Dieriks

Neuronal α-synuclein toxicity is the key driver of neurodegeneration in multiple system atrophy Wiseman et al. provide evidence that the rapid neurodegeneration observed in multiple system atrophy is driven by toxic α-synuclein fibrils invading neuron

academic.oup.com/brain/advanc...

Groundbreaking NZ-led study prompts rethink about devastating disorder NZ-led study may prove a turning point in battle against neurodegenerative disorder MSA.

Our work on MSA in the news.

www.nzherald.co.nz/nz/groundbre...

In a new paper, researchers present a refinement of the RT-QuIC protocol & analysis pipeline that can distinguish between #Parkinsons & #MSA, plus between MSA phenotypes
translationalneurodegeneration.biomedcentral.com/articles/10....

Tonga, Samoa and Guam

🧠🌍 Quiz Time!

Take a close look at this image: 🗺️
❓ Can you name these three countries?
Hint: They share a surprising connection to Parkinson's disease.
Drop your answers below and let's discuss! 🧬🗨️
#Parkinsons #HealthQuiz

Happy New year everyone! Let make 2025 a good one!! #newyear

I’m on holiday but want to share our latest published work on alpha synuclein, before I get beaten to it by @scienceofpd.bsky.social I will post the highlights in the new year. Even is you do not do PD research, I recommend looking at it for the amazing images!! rdcu.be/d4Vzd

4/4 A huge thanks to our team and collaborators for their hard work and dedication! This advancement could pave the way for a better understanding of Parkinson's early on. Stay tuned for more updates!
Thanks to our funders
HRCNewZealand
FMHS_UoA
AucklandUni
NeurologicalNZ
AMRF

CHIER protocol

3/4 We've pioneered a new antigen retrieval protocol: 'Cyclic Heat-Induced Epitope Retrieval (CHIER).' This innovative method significantly boosts the detection of SMARCC2 cytobodies, without compromising the integrity of other epitopes. 🧪🔬

SMARCC2 Cytobodies

2/4 SMARCC2, known for its role in chromatin remodelling and transcription regulation, forms unique honeycomb-structured cytobodies in neurons. Our findings show an increase in these cytobodies in Parkinson's Disease, suggesting a potential role in early disease progression.

Enhanced detection of distinct honeycomb-structured neuronal SMARCC2 cytobodies in Parkinson’s Disease via Cyclic Heat-Induced Epitope Retrieval (CHIER) Antigen retrieval is crucial for immunohistochemistry, particularly in formalin-fixed paraffin-embedded brain tissue, where fixation causes extensive crosslinking that masks epitopes. Heat Induced Epi...

🎉 Excited to share our latest work: "Enhanced detection of distinct honeycomb-structured neuronal SMARCC2 cytobodies in Parkinson’s Disease via Cyclic Heat-Induced Epitope Retrieval (CHIER)." Two key insights in this thread! 🧵 1/4
journals.plos.org/plosone/arti...

Home | Dieriks Lab - Untangling α-synuclein strains Studying the complex interactions of α-synuclein in Parkinson's disease and multiple system atrophy. Our goal is to find the cellular and molecular mechanisms underlying these neurodegenerative disord...

Thanks to my PhD students JamesAWiseman and KreesanReddy for all their work, and the invaluable support from mentors and funders (HRCNewZealand, FMHS_UoA, AucklandUni, NeurologicalNZ, AMRF and MedtechNZ) dierikslab.com

Understanding this balance and its timing is crucial, as it may determine the severity of different α-synucleinopathies. Incorporating this knowledge into future studies is vital.

The diversity in α-Syn strains, truncations, and post-translational modifications contributes to the variability observed in these disorders. The critical point at which α-Syn aggregation shifts from a consequence to a driving force in disease progression remains unknown.

The initiation of α-Synuclein (α-Syn) aggregation appears to be triggered by disease factors—both genetic and environmental. In genetic forms of Parkinson's Disease (PD) and atypical α-synucleinopathies, this interplay is complex.

How can a single protein orchestrate a vast array of diseases from early development to advanced age?

From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies This review provides an in-depth analysis of the complex role of alpha-synuclein (α-Syn) in the development of α-synucleinopathies, with a particular …

I'm excited to share our latest manuscript: "From Onset to Advancement: The Temporal Spectrum of Alpha-Synuclein in Synucleinopathies." in Aging Research Reviews. A thread:
sciencedirect.com/science/arti...
We asked one question:

Keen to connect with others and discover breakthrough research on Bluesky. My focus is on #Parkinson’sDisease, #MSA, #Synuclein

Can I get added please?