That's quite the bucket (vat?)
Just when I thought I couldn't despair of UKRI any more. This is no way to run a call, let alone one with funding of this magnitude.
Exited to share Current Opinion review on how chromatin hubs involving multiple enhancers and promoters are formed, and their potential roles in gene regulation: www.sciencedirect.com/science/arti...
It super exciting how quickly tools to unlock #IDR function are developing- can't wait to give this a try!! Congrats again!
We missed scoring 96 this round! Scoring 17000 applications and making decision is not a easy task. Better go with lottery model after prescreening.
Thank you Charlene
Thank you, Stefan
Thank you Nezha
congrats Andrew
Thank you Sara
Thank you Marco
Thank you Duncan
Work funded by @bartscharity.bsky.social & @ukri.org Excellent collaborations and lab members for their contributions, @qmulepigenetics.bsky.social & colleagues for feedback.
Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
Spend months during last summer writing a MRC grant, hoping that we will have finding to continue employing postdocs in the lab. This week l am already expecting to receive a disheartening message from UKRI.
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
We need to be shouting about the effects of this on junior researchers from the roofs, writing to our MPs. We are risking a "missing generation" of researchers.
Looks interesting looking forward to reading it. Congratulations @ioansarr.bsky.social @kaessmannlab.bsky.social
I have grant under consideration and I have already given up on this round :(
How could you reveal this on social media?
Did you not sign a naan-disclosure agreement?
Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5.
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
A human embryo implantation model from the @Rugg-Gunn Lab
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
Better added at the beginning 😁
The TArgeted Cohesin Loader (TACL) paper was just published. Happy that we were able to contribute to this really exciting project!
If you want to learn how targeting cohesin to defined loci in the genome affects the local chromatin environment and transcription, look no further!
rdcu.be/eLiT5
Just back to work after a brief subbatical
If you are the market for this, I can highly recommend!
A really useful; thank you, Lucas Farnung lab, for making this tool. We will be using it right away!
We have added additional functionalities including a collapsible protein pane and zoom scrolling. domaindesigner.farnunglab.com
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
Congratulations Martha and @scaffidilab.bsky.social
