Rohit Thakur

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics and/or Computational Biology at Aarhus University, Denmark - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University

Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… https://nat.au.dk/en/about-the-faculty/vacant-positions-and-career/job/tenure-track-assistant-professor-associate-professor-in-bioinformatics-and-or-computational-biology-at-aarhus-university-denmark #job

I am a comp bio person, it took me forever to create a plot from an analysis and write a code for it. Student took a screenshot of the plot, fed to ai, it created the code just in seconds as I watched it happen, shocked and amazed at the same time. It gave instructions which were pretty accurate

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests.

We describe a critical concept that we call *specificity*.

Led by Jeff Spence and Hakhamanesh Mostafavi:

Specificity, length and luck drive gene rankings in association studies - Nature Genetic association tests prioritize candidate genes based on different criteria.

How do GWAS and rare variant burden tests rank gene signals?

In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!

🧬🧪🧵

www.nature.com/articles/s41...

Thank you

2025 ASHG Advocacy Award Anthony Wynshaw-Boris, MD, PhD ASHG

🎖️Congratulations to Anthony Wynshaw-Boris, MD, PhD, winner of the ASHG 2025 Advocacy Award! Learn more about the award and Dr. Wynshaw-Boris's work: https://www.ashg.org/membership/awards/2025-awardees/ #ASHG #HumanGenetics

I would love to know more about this initiative, and how can we contribute?

Conservation of chromatin states and their association with transcription factors in land plants The complexity of varied modifications of chromatin composition is integrated in archetypal combinations called chromatin states that predict the local potential for transcription. The degree of conse...

New Pre-print! A long-standing question for transcription factor biology is how their chromatin context dependency works in plants. In this collaboration with Fred Berger lab, we present some new ideas not only in Arabidopsis but also in Marchantia. www.biorxiv.org/content/10.1...

Just in time for the holiday weekend--our July issue is online! Check out the latest human #genetics & #genomics research & commentary
www.cell.com/ajhg/current

Abstracts Abstract submission for ASHG 2025. We encourage you to submit your latest research on human genetics and genomics for programming at the ASHG 2025 Annual Meeting.

It's time to submit abstracts for ASHG 2025! It's going to be a fantastic meeting in Boston. Hope to see you there!
www.ashg.org/meetings/202...

Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets We utilized a custom, GWAS region-focused capture-HiC assay in human melanocytes to map physical associations between melanoma-risk-associated credible causal variants to protein-coding gene promoters...

🚨New from @rohit-thakur.bsky.social et al!
📄Mapping chromatin interactions at #melanoma susceptibility loci uncovers distant cis-regulatory gene targets

Delighted to contribute, along with locally @adwellspenn.bsky.social & @alessandrachesi.bsky.social‬. "Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets" @chopresearch.bsky.social @penngenetics.bsky.social
authors.elsevier.com/c/1l8KggeXDz0y

ASHG is deeply troubled by the recent layoffs at a number of agencies. The impact on scientific progress and innovation is profound and alarming.

Read our statement: www.ashg.org/publications...

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and...

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
@science.org @ksusztak.bsky.social
www.science.org/doi/10.1126/...

Sorry to hear that. Also space limitations?!?

JXTX + CSHL 2025 Biology of Genomes Scholarship JXTX + CSHL 2025 Biology of Genomes Scholarship

We are now accepting applications for scholarships to the @cshlaboratory.bsky.social Biology of Genomes meeting from the @jxtxfoundation.bsky.social. Open to students worldwide in support of open science. Please help spread the word! jxtxfoundation.org/news/2025-2-...

220 novel gene, how does that work for cancer evolution are they over shared over genomic regions ?

A pan-cancer atlas of T cell targets T-cell-based immunotherapies have revolutionized cancer treatment, yet only a minority of patients respond to these approaches, significantly constrained by the limited knowledge of tumor-specific ant...

What the next 🔥hot🔥 path for cellular therapies?

Check out a pan-cancer assessment 👇

You'll be keen to notice the role of 🔎 #microproteins and small ORFs.😜

🧬 💻
🧪
#genomics
#bioinformatics
#CANsky
#ImmunoSky
#RNAsky

www.biorxiv.org/content/10.1...

Khanh Trang in our @elife.bsky.social paper integrates 3D genomic maps for >50 diverse cell types with pediatric obesity GWAS. Findings implicate a role for pancreatic islet cell types. Our #V2G mapping nominates effector genes. @penngenetics.bsky.social
doi.org/10.7554/eLif...

Data released by the U.S. Department of Agriculture which showed that over 20 million egg-laying chickens in the U.S. were killed by H5N1 bird flu in the last quarter of 2024.

It can be a life line in some cases, if authors invested all time and effort in doing things one way, and the reviewer wants you try another way, both ways are correct, just multiple ways of approaching a problem. Having a lifeline like this saves time from doing things that don’t add to the story

We are recruiting a postdoc to join our team (myself, Boris Bastian, and Iwei Yeh) at UCSF to develop a pre-cancer atlas of skin cancer -- part of the Human Tumor Atlas Network (#HTAN). #CancerEvolution #Bioinformatics. Interested? Email resume and cover letter to me.

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma We performed multi-omic profiling of epidermal keratinocytes, precancerous actinic keratoses, and squamous cell carcinomas to understand the molecular transitions during skin carcinogenesis. Single-ce...

We have an update to our preprint, "Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma", which is part of the Human Tumor Atlas Network (HTAN). Also, the first manuscript post from the Shain lab to Blue Sky! www.biorxiv.org/content/10.1...

📢 Calling all future cancer researchers! Adaptmet is offering 16 MSCA PhD positions in cutting-edge metastasis research. Follow this thread & get to know the exciting projects on offer among Europe’s best teams from top host institutions! More details 👉https://adaptmet.eu/recruitment/

Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis-regulation Genome-wide association studies (GWAS) of melanoma risk have identified 68 independent signals at 54 loci. For most loci, specific functional variants and their respective target genes remain to be es...

Our recent preprint about using a custom chromatin capture assay, to identify potential target genes for cancer risk variants. For several variants, the target gene for cis regulation was ~ +/- 1Mb away, and we experimentally confirmed this for multiple targets.
www.medrxiv.org/content/10.1...