Michelle Kueppers

One-of-a-kind microscope reveals living cells in unprecedented detail Stanford researchers have combined two microscopy techniques to create a one-of-a-kind instrument that can show cell structures interacting in real time at an unprecedented 120-nanometer resolution—the highest achieved without the use of fluorescent labels.

A new label-free microscope enables real-time imaging of living cells at 120-nanometer resolution, allowing observation of cellular structures and interactions without fluorescent labels. doi.org/hbrfqk

Interferometric Image Scanning Microscopy for label-free imaging at 120 nm resolution inside live cells https://www.biorxiv.org/content/10.1101/2025.09.19.677416v1

Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM - Nature Methods The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic p...

Incredible new work from Yongdeng Zhang demonstrating live 4Pi SIM--and in two colors! www.nature.com/articles/s41...

Imaging of cellular dynamics from a whole organism to subcellular scale with self-driving, multiscale microscopy Nature Methods - A self-driving multiresolution light-sheet microscope enables the simultaneous observation and quantification of cellular and subcellular dynamics in the context of intact and...

The self-driving multiscale microscope from @daetwylerstephan.bsky.social is out.

It can image an entire zebrafish embryo longitudinally and follow a volume of interest over time with high resolution.

We used it to study cancer-immune cell interactions.

www.nature.com/articles/s41...

I thought #fluorescencefriday would be a good opportunity for my first post here. Here are some crazy actin dynamics imaged with TIRF

This is a movie of actin filaments in a cultured cell. I like watching it and I hope you do to.

Rat hippocampal neurons in culture labeled for ßII-spectrin (blue), ßIV-spectrin (yellow) and map2 (orange)

Some nice neurons for #FluorescenceFriday 😎
This image is also the banner of preLights (prelights.biologists.com), the excellent website of @biologists.bsky.social dedicated to highlighting preprints

Let's unleash the axonal growth cones for this #Fluorescencefriday ! #neuroscience #Liveimaging #microscopy #Axonguidance

Great, thank you! :)

Hi, I am a physicist working as postdoc in the field of biophotonics. This is our lab web.stanford.edu/group/moerner/
and this is one of my latest publications www.nature.com/articles/s41...
Could you please add me to the Science feed?