Anastasia Gusach

Structure of the Gq-coupled adhesion receptor ADGRL4 - Nature Communications ADGRL4 is a cancer-implicated adhesion GPCR whose ability to couple to G proteins had been unclear. Here, authors show that ADGRL4 weakly engages Gq and determine its 3.1 Å active-state structure, rev...

One last accomplishment of 2025 🎉 Our paper on the structure of an adhesion receptor ADGRL4 implicated in cancer. Very happy to have contributed!
Congratulations David, @qcchen.bsky.social and others!

www.nature.com/articles/s41...

Excited to share a new chapter of my scientific journey in Chris Russo's group — developing a way to freeze proteins faster than they diffuse, paving the way for cryo-EM without air–water interface damage.