Behnam Nabet

Are you an undergrad looking for a summer internship? Application season is underway! Check out these internship opportunities at Fred Hutch.

Apply now: linktr.ee/fredhutch

#datascience #statistics #labexperience

Kinase atlas uncovers hidden layers of cell signaling regulation See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.

New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2

So many phenomenal pumpkins at this year’s carving contest!

Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!

When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!

Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.

See here:
www.sciencedirect.com/science/arti...

Harold M. Weintraub Graduate Student Award Annual award to honor the bold, creative, pioneering spirit embodied by Hal Weintraub. The Harold M. Weintraub Graduate Student Award recognizes outstanding achievements during graduate studies in the...

The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/research/...

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12 Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…

Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social

www.sciencedirect.com/science/arti...

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.

Descriptions and links in the following two posts.

Human cytomegalovirus induces neuronal gene expression through IE1 for viral maturation - Nature Communications HCMV rearranges the host cell to produce infectious virus but molecular details are still unclear. Here, the authors analyze the transcriptome of infected cells and show that HCMV turns on dormant neu...

Excited to share our latest paper on how macroH2A is targeted by IE1 during HCMV infection- featured as an editors pick in Nature Communications! Fantastic work by Laurel and team!!

www.nature.com/articles/s41...

The first Nabet lab paddle boarding outing was a success! Couldn’t be prouder of this amazing group — grateful to lead such a committed, collaborative, and inspiring team.

The cover picture depicts a firefly (BSJ-04-146) luring a moth (FAK) to the carnivorous plant (proteasome) and was designed by DrawImpacts.

We turn complex science into striking visuals, like this cover we illustrated for Dr. @behnamnabet.bsky.social et al. on FAK inhibitors and PROTACs. 🦋
👩‍🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt

🎉 2025 DFCI TPD event registration is open!
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI

Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA Assistant/Associate Professor, Chemical Biology job

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...

Postdoc positions available! Please re-post!

Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org

Plug: @sauravk05.bsky.social is hitting the faculty job market, aiming to launch the Kumar lab in 2026. He’s truly exceptional and is building a cutting-edge induced proximity research program. Reach out!

This study was a fantastic collaboration with @fleurmferguson.bsky.social, @afederation.bsky.social, Andrea Gutierrez, Mia Donald-Paladino, Joy Chen, Frank Szuzlewsky, and Eric Holland. We are all grateful for funding from the NIH, NSF, and the Hartwell Innovation Fund - Swim Across America.

Development of PROTACs for targeted degradation of oncogenic TRK fusions Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whil...

🚨 New preprint!

Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson‬ lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...

Friday Afternoon Seminar (FAS), this Friday 5/16 at 4pm in Pelton. Rina Hirano, Tsukiyama Lab Elucidating 3D chromatin structure and its regulatory mechanism of rDNA in quiescence Christina Kuismi, Nabet Lab Targeted degradation of non-receptor tyrosine kinases PYK2 and FAK

Two great talks lined up for the final Friday Afternoon Seminars of the season!

For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!

www.nature.com/articles/s41...

Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions Protein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...

Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social!

We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo.

www.biorxiv.org/content/10.1...

Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome

Awesome work as usual from @davidmacphersonlab.bsky.social , wonderful to play a small part!

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

Targeted protein degradation for cancer therapy - Nature Reviews Cancer Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.

REVIEW 🚨

Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders.

📖 👇

Cell biologist and former Fred Hutch division leader Dr. Jonathan Cooper retires After 40 years of asking good questions of his own science and the science of his colleagues at Fred Hutch, cell biologist Dr. Jonathan Cooper has retired from the Basic Sciences Division.

Cell biologist and former @FredHutch.bsky.social division leader Dr. Jonathan Cooper retires. Learn about his many years of scientific discovery and time directing the Basic Sciences Division:

Standing up for science in Seattle!

These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:

Download our curated and comprehensive database of funding opportunities for early-career faculty.

Here: research.jhu.edu/rdt/funding-...

Hope to see many of my colleagues on Friday.

www.eventbrite.com/e/stand-up-f...

Science is for everyone.

For everyone to do, and for everyone to benefit from.

Weather forecast has also improved for Friday, but waterproof your posters just in case.

Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social

Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.

Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!