Svetlana Tsogoeva

Our recent work on the #OnePotSynthesis of first quinazoline–thiohydantoin fused scaffolds — exhibiting high potency against #MultidrugResistant #Leukemia — featured on the #Cover @pubs.acs.org! Congratulations to Lena, Christoph, Lars, Felix & our collaborators!🎉

pubs.acs.org/doi/10.1021/...

Asymmetric Catalysis: Recent Advances toward a More Sustainable Synthesis Asymmetric catalysis is the most sustainable means of achieving efficient production of enantioenriched compounds, which are valuable to the pharmaceutical industry and advanced functionalized materials. The field has undergone considerable development since its inception about 60 years ago. The development of new chiral ligands or organocatalysts or the discovery of new reactions all led to spectacular progress in terms of activity and enantioselectivity. In this context, this Outlook article aims to highlight major advances that demonstrate the central role of asymmetric catalysis in sustainability, with the examples discussed representing a selection shaped by the authors’ scientific perspective and sensitivity. This includes recent innovations in catalyst recycling, the use of less precious and less toxic metals in asymmetric organometallic catalysis, as well as the control of the positioning of catalytic sites, to further improve their efficiency. The development of asymmetric electrocatalysis and photocatalysis as well as of mechanochemistry and continuous flow chemistry is also discussed. Finally, the complexity and step-economy issues are raised with the presentation of relevant examples of asymmetric multicatalytic processes and new challenging transformations that include late-stage functionalization reactions, molecular edition or reactions targeting the creation of axial, planar or helicoidal chirality.

Asymmetric Catalysis: Recent Advances toward a More Sustainable Synthesis | #ACSCentralScience #Outlook by Emmanuelle Schulz & co-authors | @pubs.acs.org

pubs.acs.org/doi/10.1021/...

From Prompt to Drug: Toward Pharmaceutical Superintelligence The convergence of generative artificial intelligence (AI) platforms and automated laboratory systems is ushering in a new era of drug discovery, in which a plain-language prompt can initiate a fully ...

Check out #JustPublished Outlook "From Prompt to Drug: Toward Pharmaceutical Superintelligence" by Alex Zhavoronkov, David Gennert, and Jiye Shi | #ACSCentralScience @pubs.acs.org

pubs.acs.org/doi/full/10....

Delighted to present our research at the 14th #DrugChemistry Congress (5–8 Feb 2026) in beautiful #Antalya!💝 Many thanks to Serdar Burmaoğlu, Esen Bellur Atici, İrem Kulu, and the entire Organizing Committee for the warm invitation and excellent organization!🎉

#MedicinalChemistry #DrugDiscovery

#NewTeamMembers! Happy to welcome Julia Hierholzer, Dilara Güler, Marcus Kraus and Shipeng Song to our research team!!🎉🎉 We’re thrilled to have them on board. Welcome, Julia, Dilara, Marcus, and Shipeng!! 👩‍🔬🧑‍🔬

#chemistry #photochemistry #electrochemistry #dominoreactions #onepotreactions #PROTACs

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s

www.cell.com/cell/fulltex...

It was a great pleasure to host Prof. Christoph Schneider (Universität Leipzig) for a #GDCh lecture at @fau.de! Christoph presented his recent work on a novel #umpolung strategy for #enantioselective synthesis!
@gdch.de @ekatl.bsky.social @dubelab.bsky.social #Organocatalysis #AsymmetricCatalysis

Prof. Moungi Bawendi is on stage at ACS150 JACS Symposium: ETH Zurich

#ACS150 #JACSSymposium: @ethz.ch

Prof. Moungi Bawendi, 2023 Chemistry Nobel Laureate, is presenting a keynote lecture on ‘Quantum Dots: Looking Back, Looking Forward’. The talk covers colloidal quantum dots: history, properties, and quantum optics applications as quantum light sources.

Excited to attend the #ACS150 #JACS Symposium celebrating the 150th anniversary of the American Chemical Society and also grateful to mark 20 years as an ACS Member! @acs.org
A truly inspiring Symposium! Congratulations to the organizers & happy 150th anniversary to ACS!!🎉 @pubs.acs.org

Stanford Chem Prof Carolyn Bertozzi recently spoke with Stanford Report about her lab’s work in glycobiology - studying how sugars on cell surfaces shape immune recognition and cancer - and the critical role universities play in driving innovation. 🧬 Learn more: bit.ly/3YZ10Iz

Our recent work #JustPublished in JACS Au: tackling #MultidrugResistant #Cancer. We report a new small-molecule scaffold with exceptional activity against #Resistant #Leukemia cells and mechanistic links to p38α/MRTF-A.
⏩ pubs.acs.org/doi/10.1021/...
Well done Lena, Christoph, Lars & Felix!! 👏🎉

Pitfalls in the Modeling of Maltoside Detergents in Protein Structures This publication is Open Access under the license indicated. Learn More

🚨Excellent editorial in ACS Central Sci 📣

Thank you @carolynbertozzi.bskyverified.social for your support and to @louisflwilson.bsky.social for spotting these mistakes + drafting an excellent manuscript

#CryoEM #StructuralBiology
#vidalized

ACS Central Science pubs.acs.org/doi/full/10....

Drittmittelrekord an der FAU Mit rund 300 Millionen Euro an eingeworbenen Drittmitteln konnte die Universität 2024 als das drittmittelstärkste Jahr ihrer Geschichte verbuchen.

❗🥇Rekord: 2024 ist für die FAU das drittmittelstärkste Jahr ihrer Geschichte!

Die rund 300 Millionen Euro sind „ein Beleg für die Forschungsstärke unserer FAU“, sagt Uni-Präsident @hornegger.bsky.social. Gratulation an alle Wissenschaftlerinnen und Wissenschaftler!

www.fau.de/2025/12/news...

Photoexcited Manganese Complex of Abnormal N-Heterocyclic Carbene in Molecular Hydrogen Activation via Hydrogen Atom Transfer Pathway In this work, we show that the innate reactivity of the photoexcited state of a Mn-hydride complex can be harnessed to design the activation of the H2 molecule for catalytic applications. Such activation of molecular hydrogen by a photoexcited heavier 5d metal (Ir) complex has recently been achieved; however, it has been realized with an earth-abundant and lighter 3d metal complex. Here, we demonstrate that an in situ-generated Mn–H complex of an abnormal N-heterocyclic carbene can activate molecular hydrogen upon photoexcitation. The key to this approach lies in the fact that ground-state manganese hydride absorbs light to undergo homolytic cleavage, generating a metalloradical (Mn·) and a hydrogen atom. This, in turn, enables the formation of an O–H bond upon reaction with an aldehyde. Simultaneously, the generated Mn· can activate the H2 molecule, reproducing the Mn–H species in its ground state along with a hydrogen atom. The trapping of important intermediates, such as Mn· species and associated radical intermediates, using spectroscopic techniques confirms the mechanistic proposal involving the excited state of the Mn complex.

News from Manganese! Congratulations to Rohan who published with his former group @pubs.acs.org
Photoexcited Manganese Complex of Abnormal N-Heterocyclic Carbene in Molecular Hydrogen Activation via Hydrogen Atom Transfer Pathway #ChemSky
pubs.acs.org/doi/10.1021/...

🥳 The organomet team wishes a happy birthday to Paul (Knochel) on the occasion of his 70th birthday !!! 🎂Great work from Aurelien, Alexis and Emilie🤩🥰👏 @icn-cnrs.bsky.social @univcotedazur.bsky.social @cnrscotedazur.bsky.social @pacascf.bsky.social

Check out our editorial on the latest #ACSCentralScience #Collection featuring cutting-edge #Catalyzed #Enantioselective #OrganicSynthesis! @pubs.acs.org

#ChemSky #AcademicSky
⏩ pubs.acs.org/doi/10.1021/...

Welcome to FAU!
A new semester, full of possibilities.
40,000 minds — one spirit: curiosity, courage, openness.
We cross boundaries and move ideas into action.
Be curious. Be brave. Be FAU.
Welcome home. #MovingKnowledge

pubs.acs.org/doi/10.1021/...

Graphic design with the text: ‘Collection. ACS Central Science Open Access. Catalyzed Enantioselective Organic Synthesis. Read the Collection'

This Collection highlights the latest cutting-edge research in catalyzed enantioselective organic synthesis published in ACS Central Science.

Read now: buff.ly/FMRHo2e

Excited to share our new ☀️Collection☀️ in #ACSCentralScience, highlighting the central role of #enantioselectivity in natural product synthesis & drug discovery! ⏩ pubs.acs.org/page/acscii/...
You can read our editorial here:
⏩ pubs.acs.org/doi/10.1021/...
#Enantioselective #Catalysis @pubs.acs.org

Check out our editorial on the latest #ACSCentralScience #Collection featuring cutting-edge #Catalyzed #Enantioselective #OrganicSynthesis! @pubs.acs.org

#ChemSky #AcademicSky
⏩ pubs.acs.org/doi/10.1021/...

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

Science Fellows

Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars!

stanfordsciencefellows.stanford.edu

Copper-Catalyzed Asymmetric Cyclizative Sulfinamidation: Forging Indole-Based Stereogenic Sulfur(IV) Centers and Atropisomeric Chirality The structural prominence of indole-based sulfur-containing compounds in pharmacologically relevant substances stems from their versatile biofunctional capabilities. Despite their significance, the st...

Copper-Catalyzed Asymmetric Cyclizative Sulfinamidation: Forging Indole-Based Stereogenic Sulfur(IV) Centers and Atropisomeric Chirality | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Pleased to be part of the 30th European #Conference on #Heterocycles in Chemistry #ECHC2025! Looking forward to sharing our latest research & connecting with the community in this dynamic field. Hope to see many of you there! echc2025.com

#ChemSky #Budapest

Registration is now open for the 30th European Conference on Heterocycles in Chemistry! 🧪
Join us this summer in Budapest to explore emerging trends in heterocyclic chemistry with top experts from around the 🌍.
🗓 Early bird deadline: May 31
🔗 echc2025.com
#ECHC2025 #ChemSky

Congrats to Florian, Stone and Sam for publication of Part 1 in our collaboration with Laura Bohn's lab to explore the pharmacology of GB18, a Galbulimima alkaloid that we identified as a novel opioid in 2022.
pubs.acs.org/doi/10.1021/acscentsci.5c00573

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

Check out this amazing new work from @sattelylab.bsky.social along with collaborator and @stanford-chemh.bsky.social Institute Scholar @pollyfordyce.bsky.social !

www.nature.com/articles/s41...

It was a great pleasure to host Prof. Paolo Melchiorre for his brilliant #GDCh lecture at @nat.fau.de! Paolo’s talk highlighted how core #photochemical insights spark innovation in #AsymmetricSynthesis!

@gdch.de @dubelab.bsky.social @spanlabfau.bsky.social @harder-research.bsky.social

Happy to share that our project on novel #antiviral #PROTACs has been awarded funding by the #VolkswagenFoundation!🎉 A big thank you to the @volkswagenstiftung.de for supporting our research, and to the #MarschallGroup (Institute of Virology, @fau.de) for the great collaboration!👍