Davide Ruggero

A fascinating connection between translation decoding specificity through metabolites that help cells control a vital redox state. Congrats Josh @mendell-lab.bsky.social and Fred! @fred-rehfeld.bsky.social

This will be an exciting meeting on many aspects of RNA biology, the impact on tumorigenesis and theraupric implications. Including: Splicing, Noncoding RNA, RNA modifications, Translation, New technologies, RNA and immunology, Protein-RNA assembly, & cancer therapeutics in targeting RNA. Join us!

Small-molecule RNA therapeutics to target prostate cancer Kuzuoglu-Ozturk et al. showcase a therapeutic approach, “translatome therapy,” to combat lethal prostate cancer. Zotatifin, a clinical molecule, targets the RNA-helicase eIF4A. Zotatifin decreases the select translation of key oncogenes, androgen receptor (AR), and HIF1α through remodeling their 5′ UTR RNA structure. Zotatifin enhances anti-androgen and radiotherapy sensitivity, highlighting a promising anti-cancer treatment.

Small-molecule RNA therapeutics to target prostate cancer

Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features Understanding the interactions between various mRNA features—such as RNA modifications, poly(A) tail length, and splicing—has been highly sought after but remains largely elusive. Here, Kim and Savill...

Excited to share our first study using nanopore direct RNA seq to comprehensively characterize RNA features. We believe that our deep and high coverage datasets should be a nice resource for the field! www.cell.com/cell-genomic...

Great work Ly! Congrats!

Breaking up translation condensates in cancer - Nature Cell Biology Translational control is emerging as a key regulator of cancer. The RNA-binding protein PABPC1 is shown to drive chronic myeloid leukaemia (CML) by enhancing the translation of pro-oncogenic mRNAs thr...

🍰Interested in reading more about the study? Here's the N&Vs article written by Joanna R. Kovalski & Davide Ruggero.
👉https://rdcu.be/ejwqJ
bit.ly/4jnydWI

Ribosomal rebellion: When protein factories drive cancer progression In Cancer Cell, two studies unveil mechanisms by which co-option of the protein synthesis machinery promotes cancer progression and potential therapeutic interventions. Kuzuoglu-Ozturk et al. show that eIF4A-mediated enhancement of oncogenic transcript translation initiation drives cancer progression, while Weller et al. demonstrate how aberrant transfer RNA (tRNA) modification disrupts translational fidelity to produce neoantigens.

Online Now: Ribosomal rebellion: When protein factories drive cancer progression

Congrats Marvin!

Cool paper, Liron! Fascinating the connection between ROS and mitochondrial translation. Congrats to all!

Fascinating work on noncoding snoRNA sequences on ribosome biogenesis and its implication in cancer cell fitness! Congrats Josh @mendell-lab.bsky.social and team!

Thanks Levi Gadye and Laura Kurtzman for the thoughtful and creative press release! @UCSF @UCSFCancer

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And we couldn't make it without @PCFnews @pcarroll_ and Benioff Initiative for Prostate Cancer Research support!

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Thanks for the support of @AmericanCancer @UCSFUrology @NCICancerCtrl @UCSFCancer @ACS_Research

Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to ⁦@DuyguKuzuoglu⁩ an amazing postdoc and all the authors and collaborators!

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Great tools and tips for the field to study IRES-dependent translation. Beautiful dissection of true HOX IRES translation in developing embryos. Congrats to all @mbarnalab @KatLeppek!

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A tour de force in deciphering in action the intriguing dynamic composition of ribosomes in vivo. Beautiful work! Congrats to all @mbarnalab!

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Thanks Levi Gadye, for the wonderful and insightful highlight of our last publication! @UCSF

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Thanks to the authors and collaborators @rushika_perera lab. Thanks @ACS_Research @NCICancerBio for the support. @UCSFUrology @UCSFCancer

Congrats @mbarnalab @travisclantz and Christine on this award and making progress on targeting ribosomes to increase protein synthesis!

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Congrats on this beautiful paper on another great link between lipid metabolism and translation control! @DeSiqueiraMK, @ClaudioVillanu, and team!

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Amazing work on uncovering a new role for tRNAs in linking mRNA stability with codon-specific translation! Congrats @Mendell_lab and team!!

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Amazing paper on specialized ribosomes and their roles in cancer immune response! Congrats @liamfaller and all team!

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Thanks @RNACanadaC2R2 for organizing an amazing RNA meeting!

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Fantastic collaboration with the @mbarnalab @TheVictoriaHung @AndrewL85556734 Theo and team on ribosome composition in cancer, development and macrophages. @UCSFCancer @ACS_Research @StanfordMed

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Thanks for the support @ACS_Research @AmericanCancer @NCIResearchCtr @UCSFCancer @NCICancerBio @UCSFUrology

This was only possible through the many amazing team including @AndreaZingaro94 @harrison__tom and everyone that came together from metabolism to structural work all the way to mouse models. Michael Grabe James Lincoff @KajimuraLab Alma L. Burlingame, Juan A. Oses-Prieto...

During fasting and a ketogenic diet increased phosphorylation of the major cap binding protein eIF4E controls the translation of mRNAs involved in lipid catabolism and ketogenesis.

Thanks so much Levi Gadye @UCSFCancer @UCSFMedicine for this wonderful summary of our recent research!

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Congrats Daphna @D_Rothschild_ Theo, and team @mbarnalab Beautiful and important work.

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Fascinating work on noncoding snoRNA sequences on ribosome biogenesis! Congrats Josh @Mendell_lab and team!

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