Eurico Morais-de-Sá's Avatar

Eurico Morais-de-Sá

@polarityi3s

Drosophilist & Biochemist interested in cell asymmetries. Epithelial Polarity & Cell Division Lab https://www.i3s.up.pt/research-group.php?groupid=123

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12.11.2023
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Latest posts by Eurico Morais-de-Sá @polarityi3s

Research in #rarediseases using model organisms is of utmost importance to unravel the underlying molecular mechanisms of disease @rarediseaseday.bsky.social

01.03.2026 08:27 👍 6 🔁 1 💬 1 📌 0
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Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!

www.nature.com/articles/s41...

20.02.2026 13:32 👍 26 🔁 13 💬 0 📌 3
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Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en

03.12.2025 08:00 👍 35 🔁 28 💬 0 📌 6
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How do cells orchestrate themselves to achieve a directional movement as a group?

Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.

31.01.2026 08:54 👍 57 🔁 18 💬 2 📌 4
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Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.

🔗 www.biorxiv.org/content/10.6...

29.01.2026 11:32 👍 57 🔁 25 💬 1 📌 3
Cartoon with principle of Flash-away and images of cells

Cartoon with principle of Flash-away and images of cells

FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...

01.12.2025 11:36 👍 30 🔁 11 💬 0 📌 0
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It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

23.11.2025 08:01 👍 50 🔁 19 💬 1 📌 3
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Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp

12.11.2025 17:42 👍 27 🔁 34 💬 0 📌 5
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🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...

31.10.2025 14:41 👍 215 🔁 98 💬 15 📌 11
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Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…

Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social

www.sciencedirect.com/science/arti...

23.10.2025 07:14 👍 25 🔁 15 💬 5 📌 0
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Interested in cell migration and developmental biology-check out this PhD opportunity!

www.findaphd.com/phds/project...

10.10.2025 16:30 👍 6 🔁 6 💬 0 📌 0
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So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n
advanced.onlinelibrary.wiley.com/doi/10.1002/...

30.09.2025 14:29 👍 25 🔁 11 💬 1 📌 0
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See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

01.10.2025 18:20 👍 223 🔁 68 💬 11 📌 18
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🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

22.09.2025 09:37 👍 124 🔁 38 💬 9 📌 6
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How can we use cell shapes and geometry to study mechanics of tissues?

I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics

13.09.2025 07:14 👍 55 🔁 15 💬 2 📌 2
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Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...

#Reproducibility

03.09.2025 14:15 👍 37 🔁 28 💬 1 📌 4
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Advancing cancer research via comparative oncology Nature Reviews Cancer - Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular...

Happy to share a new publication: an introduction to comparative oncology in @natrevcancer.nature.com‬. Thanks to the leaders in the field for welcoming me as an invertebrate researcher.
rdcu.be/etKdN

30.06.2025 16:27 👍 21 🔁 15 💬 0 📌 0
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Epithelial morphogenesis is all about how epithelial tissues develop unique shapes and structures! I'm @nehaghosh.bsky.social and will share some research in this area.

29.06.2025 06:44 👍 32 🔁 11 💬 1 📌 2
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A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation This work introduces Flysta3D-v2, a 3D spatiotemporal multi-omics database that spans Drosophila development from embryogenesis to metamorphosis. Through the integration of multimodal data, we detail ...

A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation: Cell
1/2

www.cell.com/cell/abstrac...

28.06.2025 05:57 👍 21 🔁 8 💬 2 📌 1
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FINALLY out in #Science Advances! 🎉
3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author!

It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀

www.science.org/doi/10.1126/...

#DevBio #CellBio #Microscopy

18.06.2025 19:06 👍 213 🔁 42 💬 12 📌 5
Intestinal permeability significantly increased 30 days prior to death in AKR/J females

Intestinal permeability significantly increased 30 days prior to death in AKR/J females

Fat mass decreases significantly in the last month of life

Fat mass decreases significantly in the last month of life

body temperature drops significantly in the last month of life

body temperature drops significantly in the last month of life

extremely happy to present the final version of our "smurf mice" paper www.biorxiv.org/content/10.1..., led by Céline Cansell when she was a postdoc in my group (now an independent @inrae-france.bsky.social researcher).
Disclaimer: no blue mice here alas BUT clearly a biphasic ageing process

19.06.2025 17:06 👍 24 🔁 6 💬 3 📌 1
Cartoon showing a woman looking in to a microscope saying "Whoaah!!!" The caption states "The best part of Science is knowing, for a moment, something that nobody else in the world knows"

Cartoon showing a woman looking in to a microscope saying "Whoaah!!!" The caption states "The best part of Science is knowing, for a moment, something that nobody else in the world knows"

A reminder in these hard times. #sciencestrong

19.02.2025 06:14 👍 134 🔁 45 💬 3 📌 3
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Interphase cell morphology defines the mode, symmetry, and outcome of mitosis During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

06.05.2025 20:39 👍 169 🔁 47 💬 3 📌 3

#EDRC2025 👇🏻👇🏻👇🏻👇🏻

29.04.2025 16:12 👍 1 🔁 4 💬 1 📌 0
Program and application instructions for the 2025 Mechanobiology of tissue morphogenesis and disease workshop in Baeza, Spain, October 21-23. Apply at https://www.unia.es/estudios-y-acceso/oferta-academica/formacion-continua/workshop-mechanobiology-of-tissue-morphogenesis-and-disease

Program and application instructions for the 2025 Mechanobiology of tissue morphogenesis and disease workshop in Baeza, Spain, October 21-23. Apply at https://www.unia.es/estudios-y-acceso/oferta-academica/formacion-continua/workshop-mechanobiology-of-tissue-morphogenesis-and-disease

Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!

25.04.2025 14:07 👍 58 🔁 39 💬 1 📌 4
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#CellMigration 𝐢𝐧 𝐯𝐢𝐯𝐨!
Excited to share this video on #FluorescenceFriday 🌈
Today as a GIF to circumvent video compression 😅!

Migratory Nascent Myotubes on #Drosophila Testes. Marker: Lifeact-eGFP. Scope: 980 Airyscan (@zeiss-microscopy.bsky.social)

#cellbio #sciart #devbio #science #microscopy

25.04.2025 12:25 👍 93 🔁 18 💬 2 📌 1
Poster for the meeting including speaker list and location

Poster for the meeting including speaker list and location

Cell and developmental biologists: as you start looking at conferences in 2025, consider joining us at the 2025 Cell Contact & Adhesion GRC. We've assembled a strong and diverse program of speakers at the cutting-edge of science in our field 1/n Please repost
www.grc.org/cell-contact...

18.12.2024 15:43 👍 55 🔁 24 💬 2 📌 10
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1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”.

#cellbio #devbio #cellmigration

20.04.2025 07:31 👍 115 🔁 40 💬 3 📌 8

Muitos Parabéns Jorge! Isso tem que ser celebrado🍾

14.04.2025 19:19 👍 1 🔁 0 💬 1 📌 0
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Proximity-based activation of AURORA A by MPS1 potentiates error correction Faithful cell division relies on mitotic chromosomes becoming bioriented with each pair of sister kinetochores bound to microtubules oriented toward o…

I'm happy to share our study “Proximity-based activation of AURORA A by MPS1 potentiates error correction” now published at @currentbiology.bsky.social

www.sciencedirect.com/science/arti...

It describes a new way kinetochores and centrosomes communicate to ensure accurate chromosome segregation.

13.04.2025 01:52 👍 27 🔁 11 💬 1 📌 0