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Nature Reviews Gastroenterology & Hepatology

@natrevgastrohep.nature.com

We publish #gastroenterology & #hepatology Reviews and opinion https://www.nature.com/nrgastro/ #GastroEdPick selections by the Editors: Katrina (@heykatray.bsky.social), Jordan & Eleni #Gastrosky #LiverSky #Microsky #Medsky

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Latest posts by Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com

ECCO’26 Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01194-9ECCO’26

ICYMI: New online! ECCO’26

07.03.2026 15:18 👍 0 🔁 0 💬 0 📌 0
Long-term data for ileocaecal resection for ileal Crohn’s disease Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01193-wLong-term data for ileocaecal resection for ileal Crohn’s disease

ICYMI: New online! Long-term data for ileocaecal resection for ileal Crohn’s disease

07.03.2026 15:18 👍 0 🔁 0 💬 0 📌 0
Preview
Women’s health Research into women’s health has suffered from historical neglect and lack of funding.

To mark International Women's Day on 8th March #IWD2026, the #NatureReviews Collection on women's health has been updated (go.nature.com/30kDWG3). The Collection covers various aspects of women's health and includes a new Primer on ovarian cancer from @natrevdiseaseprimers.nature.com

06.03.2026 12:19 👍 13 🔁 12 💬 0 📌 0
ECCO’26 Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01194-9ECCO’26

New online! ECCO’26

06.03.2026 15:17 👍 0 🔁 0 💬 0 📌 0
Long-term data for ileocaecal resection for ileal Crohn’s disease Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01193-wLong-term data for ileocaecal resection for ileal Crohn’s disease

New online! Long-term data for ileocaecal resection for ileal Crohn’s disease

06.03.2026 15:17 👍 1 🔁 0 💬 0 📌 0
HIV-associated gut microbiome influences gut mucosal immunity Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01191-yHIV-associated gut microbiome influences gut mucosal immunity

New online! HIV-associated gut microbiome influences gut mucosal immunity

06.03.2026 15:17 👍 0 🔁 0 💬 0 📌 0
Microplastics and nanoplastics in the human gut: from signals to standards Nature Reviews Gastroenterology & Hepatology, Published online: 04 March 2026; doi:10.1038/s41575-026-01185-wThe gastrointestinal tract is a critical interface for microplastic and nanoplastic exposure, yet causal links to health outcomes remain uncertain. We outline current methodological challenges and provide a list of minimum standards for rigorous study design, standardized reporting and careful attention to interpretations to distinguish mechanism from signals.

ICYMI: New online! Microplastics and nanoplastics in the human gut: from signals to standards

05.03.2026 20:53 👍 2 🔁 0 💬 0 📌 0
Microplastics and nanoplastics in the human gut: from signals to standards Nature Reviews Gastroenterology & Hepatology, Published online: 04 March 2026; doi:10.1038/s41575-026-01185-wThe gastrointestinal tract is a critical interface for microplastic and nanoplastic exposure, yet causal links to health outcomes remain uncertain. We outline current methodological challenges and provide a list of minimum standards for rigorous study design, standardized reporting and careful attention to interpretations to distinguish mechanism from signals.

New online! Microplastics and nanoplastics in the human gut: from signals to standards

04.03.2026 20:52 👍 2 🔁 0 💬 0 📌 0

This new review from Core Investigator @christophthaiss.bsky.social & Innovation Investigator @maayanlevy.bsky.social maps how gut metabolites shape diseases from IBD to cancer, and lays out a framework for using them as therapies.

03.03.2026 16:57 👍 4 🔁 3 💬 0 📌 0
Preview
Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.

ICYMI: New online! Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut

03.03.2026 20:48 👍 2 🔁 0 💬 0 📌 0
Preview
Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.

New online! Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut

02.03.2026 20:47 👍 5 🔁 2 💬 0 📌 1
COVER: Improving surgery for liver cancer, inspired by the Review starting on p208.

COVER: Improving surgery for liver cancer, inspired by the Review starting on p208.

Our MARCH ISSUE is live! Surgery in HCC, abdominal pain in IBD, WNT–β-catenin signalling in HCC, liver disease and HIV infection, and much more!

www.nature.com/nrgastro/vol...

02.03.2026 08:20 👍 4 🔁 1 💬 1 📌 0
Hepatitis C elimination: is it time to redefine the goals? Nature Reviews Gastroenterology & Hepatology, Published online: 23 February 2026; doi:10.1038/s41575-026-01184-xDirect-acting antiviral agents have substantially improved the rate of sustained virologic response and safety in the treatment of hepatitis C. However, concerns about the long-term outcomes for individuals who achieve sustained virologic response still exist. Herein, we propose a new conceptual model for redefining the goals and strategies of ongoing hepatitis C elimination campaigns.

ICYMI: New online! Hepatitis C elimination: is it time to redefine the goals?

01.03.2026 20:45 👍 2 🔁 0 💬 0 📌 0
The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view Nature Reviews Gastroenterology & Hepatology, Published online: 19 February 2026; doi:10.1038/s41575-026-01179-8The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view

ICYMI: New online! The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view

26.02.2026 08:48 👍 1 🔁 0 💬 0 📌 0
Image of Nature Reviews Gastroenterology & Hepatology paper, "The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health," by Maria L. Marco, Marla Cunningham, Stephan C. Bischoff, Gerard Clarke, Nathalie Delzenne, James D. Lewis, Marlies Meisel, Daniel Merenstein, Paul W. O'Toole, Heidi M. Staudacher, Hania Szajewska, Jerry M. Wells, and Eamonn M. M. Quigley.

Image of Nature Reviews Gastroenterology & Hepatology paper, "The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health," by Maria L. Marco, Marla Cunningham, Stephan C. Bischoff, Gerard Clarke, Nathalie Delzenne, James D. Lewis, Marlies Meisel, Daniel Merenstein, Paul W. O'Toole, Heidi M. Staudacher, Hania Szajewska, Jerry M. Wells, and Eamonn M. M. Quigley.

What is gut health? A new consensus statement in @natrevgastrohep.nature.com , co-authored by @meisellab.bsky.social, finally defines it—and outlines a framework for research and clinical practice. Read it here: www.nature.com/articles/s41...

25.02.2026 19:00 👍 3 🔁 2 💬 0 📌 0
Hepatitis C elimination: is it time to redefine the goals? Nature Reviews Gastroenterology & Hepatology, Published online: 23 February 2026; doi:10.1038/s41575-026-01184-xDirect-acting antiviral agents have substantially improved the rate of sustained virologic response and safety in the treatment of hepatitis C. However, concerns about the long-term outcomes for individuals who achieve sustained virologic response still exist. Herein, we propose a new conceptual model for redefining the goals and strategies of ongoing hepatitis C elimination campaigns.

ICYMI: New online! Hepatitis C elimination: is it time to redefine the goals?

24.02.2026 20:44 👍 2 🔁 0 💬 0 📌 0
Post image

Gut health is everywhere, but what does it mean, how can it be measured, and what are its health implications?

This hot off the press @isappscience.bsky.social led review article in @natrevgastrohep.nature.com  updates what every healthcare professional needs to know:

https://tinyurl.com/zaf6hahw

23.02.2026 15:03 👍 5 🔁 2 💬 0 📌 0
Preview
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health Nature Reviews Gastroenterology & Hepatology, Published online: 18 February 2026; doi:10.1038/s41575-026-01176-xThis Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term in the context of therapeutic interventions.

ICYMI: New online! The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health

24.02.2026 18:23 👍 5 🔁 2 💬 0 📌 0
Hepatitis C elimination: is it time to redefine the goals? Nature Reviews Gastroenterology & Hepatology, Published online: 23 February 2026; doi:10.1038/s41575-026-01184-xDirect-acting antiviral agents have substantially improved the rate of sustained virologic response and safety in the treatment of hepatitis C. However, concerns about the long-term outcomes for individuals who achieve sustained virologic response still exist. Herein, we propose a new conceptual model for redefining the goals and strategies of ongoing hepatitis C elimination campaigns.

New online! Hepatitis C elimination: is it time to redefine the goals?

23.02.2026 20:43 👍 0 🔁 0 💬 0 📌 0
The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view Nature Reviews Gastroenterology & Hepatology, Published online: 19 February 2026; doi:10.1038/s41575-026-01179-8The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view

ICYMI: New online! The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view

21.02.2026 08:47 👍 1 🔁 1 💬 0 📌 0
Reply to ‘The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view’ Nature Reviews Gastroenterology & Hepatology, Published online: 19 February 2026; doi:10.1038/s41575-026-01177-wReply to ‘The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view’

ICYMI: New online! Reply to ‘The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view’

21.02.2026 08:47 👍 0 🔁 0 💬 0 📌 0
The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view Nature Reviews Gastroenterology & Hepatology, Published online: 19 February 2026; doi:10.1038/s41575-026-01179-8The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view

New online! The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view

20.02.2026 08:46 👍 0 🔁 0 💬 0 📌 0
Reply to ‘The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view’ Nature Reviews Gastroenterology & Hepatology, Published online: 19 February 2026; doi:10.1038/s41575-026-01177-wReply to ‘The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view’

New online! Reply to ‘The ethics of unlicensed therapy use in primary biliary cholangitis: a counter view’

20.02.2026 08:46 👍 1 🔁 0 💬 0 📌 0
Preview
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health Nature Reviews Gastroenterology & Hepatology, Published online: 18 February 2026; doi:10.1038/s41575-026-01176-xThis Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term in the context of therapeutic interventions.

ICYMI: New online! The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health

19.02.2026 18:21 👍 4 🔁 1 💬 0 📌 0
Preview
Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis Nature Reviews Gastroenterology & Hepatology, Published online: 12 February 2026; doi:10.1038/s41575-026-01175-ySteatotic liver diseases affect millions worldwide through alcohol and metabolic insults. This Review highlights steatotic liver disease genetic architecture, how it informs disease biology, drug discovery and risk stratification through polygenic risk scores and the need for improved clinical applications.

ICYMI: New online! Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis

18.02.2026 20:52 👍 0 🔁 0 💬 0 📌 0
Preview
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health Nature Reviews Gastroenterology & Hepatology, Published online: 18 February 2026; doi:10.1038/s41575-026-01176-xThis Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term in the context of therapeutic interventions.

New online! The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health

18.02.2026 18:20 👍 10 🔁 4 💬 0 📌 0
Hepatic recompensation in patients with alcohol-related cirrhosis after alcohol cessation Nature Reviews Gastroenterology & Hepatology, Published online: 11 February 2026; doi:10.1038/s41575-026-01181-0Hepatic recompensation in patients with alcohol-related cirrhosis after alcohol cessation

ICYMI: New online! Hepatic recompensation in patients with alcohol-related cirrhosis after alcohol cessation

17.02.2026 20:48 👍 0 🔁 0 💬 0 📌 0
In vivo-generated anti-FAP CAR T cells reduced fibrosis in MASH mice Nature Reviews Gastroenterology & Hepatology, Published online: 11 February 2026; doi:10.1038/s41575-026-01183-yIn vivo-generated anti-FAP CAR T cells reduced fibrosis in MASH mice

ICYMI: New online! In vivo-generated anti-FAP CAR T cells reduced fibrosis in MASH mice

17.02.2026 20:48 👍 1 🔁 0 💬 0 📌 0
Nutritional maintenance therapy for paediatric patients with Crohn’s disease Nature Reviews Gastroenterology & Hepatology, Published online: 11 February 2026; doi:10.1038/s41575-026-01180-1Nutritional maintenance therapy for paediatric patients with Crohn’s disease

ICYMI: New online! Nutritional maintenance therapy for paediatric patients with Crohn’s disease

17.02.2026 20:48 👍 0 🔁 0 💬 0 📌 0
ENPP1 as a contributor to chronic pancreatitis-related PDAC Nature Reviews Gastroenterology & Hepatology, Published online: 11 February 2026; doi:10.1038/s41575-026-01182-zENPP1 as a contributor to chronic pancreatitis-related PDAC

ICYMI: New online! ENPP1 as a contributor to chronic pancreatitis-related PDAC

17.02.2026 20:48 👍 0 🔁 0 💬 0 📌 0