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Anders Huitfeldt

@andershuitfeldt.net

Aspiring rationalist. Medical doctor (PGY 5, addiction medicine). In a past life, I was an epidemiologist. MB BCh BAO (Royal College of Surgeons in Ireland, 2008). ScD (Harvard School of Public Health, 2015).

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Latest posts by Anders Huitfeldt @andershuitfeldt.net

In my view, approximate correctness of the model (in terms of biological plausibility) is lexicographically more important to model choice than tractability of the estimation procedure (provided that researchers honestly discuss how that might affect their inferences)

09.01.2026 09:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

You can of course argue that oppressed groups tend to be assigned tougher judges because of discrimination. Then you should not control for judge because it is a mediator. But for conceptual clarity, this is different from your stated reason for not controlling

08.12.2025 15:28 πŸ‘ 2 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0

I think I disagree with this. Suppose you have sufficient data to control for judge on the individual judge level and the only relevant bias is whether the judges are prejudiced. Then controlling for judge will give you a model that appropriately detects such bias.

08.12.2025 15:26 πŸ‘ 1 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
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Why science needs outsiders - Works in Progress Magazine Science has forgotten that the greatest breakthroughs often come from outsiders who are able to take a fresh perspective.

Fun article about β€œoutsider” scientists and their breakthroughs.

β€œAcademia filters most funding, publishing, and hiring decisions through senior insiders, which favors ideas within existing paradigms.”

worksinprogress.co/issue/why-sc...

19.09.2025 04:29 πŸ‘ 121 πŸ” 42 πŸ’¬ 10 πŸ“Œ 3
Goose chase meme. Goose asks "Unbiased for what estimand?" then yells "Unbiased for what!!"

Goose chase meme. Goose asks "Unbiased for what estimand?" then yells "Unbiased for what!!"

Reckon I can submit this as a figure for a paper?

09.07.2025 10:21 πŸ‘ 100 πŸ” 14 πŸ’¬ 4 πŸ“Œ 0
Foreground text says β€œMarginal” and β€œconditional” are relative descriptions of an estimand
In the background is a smokey mollusc

Foreground text says β€œMarginal” and β€œconditional” are relative descriptions of an estimand In the background is a smokey mollusc

New post: β€œMarginal” and β€œconditional” are relative descriptions of an estimand

07.07.2025 15:10 πŸ‘ 13 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0
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When do composite estimands answer non-causal questions? Under a composite estimand strategy, the occurrence of the intercurrent event is incorporated into the endpoint definition, for instance by assigning a poor outcome value to patients who experience th...

New paper posted on Arxiv: "When do composite estimands answer non-causal questions?"

This can happen more often than you think, and can have a dramatic impact on trial results (e.g. a false-positive rate of almost 90%)

arxiv.org/abs/2506.22610 @timpmorris.bsky.social

01.07.2025 09:31 πŸ‘ 12 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0

Suppose someone went to a discussion board whose community values differ more from ours than those of the β€œred tribe” (e.g islamists, putinists or CCP ideologues). Wouldn’t you think this was a good thing, helping both sides understand better how the others see the world?

01.03.2025 14:52 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

That’s fine. You can stay away from them as much as you want. I just dont get the rationale for shaming people for engaging β€œthe other side” in conversation

01.03.2025 14:45 πŸ‘ 1 πŸ” 0 πŸ’¬ 4 πŸ“Œ 0

You can be a moral purist all you want, but honestly, what is your end game? Do you expect the β€œother faction” to just all suddenly come to the realization that you were right all along, and that they were contemptible bigots who had been mislead by disinformation ?

01.03.2025 13:21 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

If we want to find a way to live alongside people who don’t share our values, the first step will be to find a way to communicate across the sociocultural fault line. That requires that we do not wall ourselves into separate corners of the internet

01.03.2025 13:19 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Should one derive risk difference from the odds ratio? I urge all readers of this thread to read the excellent new preprint from philosopher of science Veli-Pekka Parkkinen, β€œChoice of effect measure, extrapolation, and decision-making in patient care an...

After two years of trying to avoid this discussion, I just necroed *that thread* on datamethods (discourse.datamethods.org/t/should-one...) in order to share an excellent preprint by philosopher Veli-Pekka Parkkinen (philsci-archive.pitt.edu/24785/1/efme...)

26.02.2025 10:00 πŸ‘ 9 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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I’m George Takei and I approve of this message.

19.02.2025 15:47 πŸ‘ 144055 πŸ” 30022 πŸ’¬ 2291 πŸ“Œ 1514

Β«The world is what it is; men who are nothing, who allow themselves to become nothing, have no place in itΒ»

01.02.2025 20:31 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

🀒 horrifying piece of work, which we’ll see idiots quoting.
For goodness sake @jclinepi.bsky.social

03.01.2025 13:39 πŸ‘ 42 πŸ” 7 πŸ’¬ 8 πŸ“Œ 3
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In economics, editors, referees, and authors often behave as if a published paper should reflect some kind of authoritative consensus.

As a result, valuable debate happens in secret, and the resulting paper is an opaque compromise with anonymous co-authors called referees.

1/

24.12.2024 14:44 πŸ‘ 554 πŸ” 159 πŸ’¬ 28 πŸ“Œ 33
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a cartoon of homer simpson and marge simpson with the words you tried your best Alt: a cartoon of homer simpson and marge simpson with the words you tried your best and you failed miserably, the lesson is never try.

People say estimating a causal effect sets the bar unattainably high.

But estimating an association is a bar that is literally so low that you can't go under it.

Better to aim for what you want and fall short than to, in Homer Simpson's words, "aim so low, no one will even care if you succeed."

10.12.2024 14:08 πŸ‘ 18 πŸ” 4 πŸ’¬ 4 πŸ“Œ 1

While most of the alternatives to democracy have been tried, there are many alternatives to the publishing system that have not been tried and may be superior.

10.12.2024 22:58 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I was not trying to make a point about inexact wording, and I apologize if that is how it came across. My point was that there may exist better systems for evaluating science that have not been tried.

10.12.2024 22:58 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I believe the quote was "all the others that have been tried". The system was well suited for an era when the limiting factor was the cost of printing and distributing paper journals. When distribution of information is essentially free, other systems may work better for identifying scientific value

10.12.2024 22:37 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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The Justice Department has filed a lawsuit against approximately two dogs.

10.12.2024 20:50 πŸ‘ 3349 πŸ” 602 πŸ’¬ 208 πŸ“Œ 404

Unpopular opinion: Blinded peer review was a mistake. If someone is able to block my paper based on their midwit opinions, they should at the very least be forced to put their name on the review, and publicly stake their reputation on the (false) claim that my work is flawed.

10.12.2024 21:44 πŸ‘ 2 πŸ” 0 πŸ’¬ 3 πŸ“Œ 0

Same. Have no desire to speak ill of the dead, but I wished they had left this sentence out of the obituary: "He will be remembered for his remarkable contributions to the psychology world and as a defender of expression without undue fear of reprisal." Simply not true.

06.12.2024 15:25 πŸ‘ 8 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

The data used for this map seems off. Having worked in hospitals in both countries, I refuse to believe that the death rate in Norway is double the rate in Ireland

05.12.2024 14:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Can anyone point me to a convincing intro to / explanation of β€˜in silico’ trials?
Everything I’ve read & heard about them just makes the writer/presenter sound nuts.
What am I missing??

04.12.2024 09:04 πŸ‘ 28 πŸ” 3 πŸ’¬ 6 πŸ“Œ 3

The Onion should buy Elsevier next

14.11.2024 20:28 πŸ‘ 5378 πŸ” 1583 πŸ’¬ 57 πŸ“Œ 82

I like this taxonomy, but the examples given are not convincing. Most missingness is dependent on unseen data, so I understand that it is difficult to find good examples, but they could have tried to find some plausible random missingness mechanism for illustration

11.11.2024 11:54 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Gotta be honest here, Rhian is one of my favorite authors. I always enjoy her papers so much. I’m currently reading her paper on collapsibility and I feel like this one will be a natural follow up.

15.10.2024 00:56 πŸ‘ 7 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0
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The averted infections ratio: a novel measure of effectiveness of experimental HIV pre-exposure prophylaxis agents There is clear evidence that tenofovir disoproxil fumarate combined with emtricitabine (TDF-FTC) is a highly efficacious oral pre-exposure prophylaxis agent for preventing the acquisition of HIV. This...

One for @andershuitfeldt.bsky.social (icymi)

www.ncbi.nlm.nih.gov/pmc/articles...

03.10.2024 08:40 πŸ‘ 5 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

At the moment it is not publicly available. A new, substantially rewritten version will be made available in the not too distant future

18.09.2024 13:07 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0