Dr. David Boulware, MD MPH's Avatar

Dr. David Boulware, MD MPH

@drboulware

Professor of Medicine at U of MN; Practicing infectious disease doc; budding mycologist; interested in cryptococcal & TB meningitis. Ran some RCTs during COVID, but more excited to return to focus on RCTs on HIV-related meningitis & advanced HIV disease

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Latest posts by Dr. David Boulware, MD MPH @drboulware

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

07.03.2026 01:59 πŸ‘ 624 πŸ” 375 πŸ’¬ 19 πŸ“Œ 57

Well, gas is expensive, and food is expensive, and we’re doing a war nobody wants, but at least there are no jobs

06.03.2026 19:47 πŸ‘ 30000 πŸ” 7414 πŸ’¬ 225 πŸ“Œ 237

I am out of the country at present, so I may have missed it but has Congress declared war on Iran as per Article I, Section 8 of the Constitution of the United States?

07.03.2026 05:13 πŸ‘ 3 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
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Immunomodulation in the Treatment of Disseminated Coccidioidomycosis Severe coccidioidomycosis carries high mortality despite antifungals. We treated 18 refractory cases with immune modulation, including augmentation of Type

More adjunctive immunomodulation for an infectious disease!

Here it's dupilumab (IL-4/13 blockade) in coccidioidomycosis.

Case series only, but not overtly harmful and maybe even helpful.

#IDSky #immunosky

academic.oup.com/cid/advance-...

05.03.2026 07:38 πŸ‘ 13 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0

Is it an operation like having one's appendix removed?

05.03.2026 08:10 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Whose Airstrike Hit a Girls’ School in Iran? The U.S. Says It’s Still Investigating.

Alas, US is now investigating. Unfortunately, the same US govt that shoots citizens in Minneapolis calling them domestic terrorists has zero credibility for being truthful. www.nytimes.com/2026/03/04/u...

05.03.2026 08:08 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Unfortunately, none of the three governments has much credibility.
I would guess a failed missile launch is more likely, unless AI was hallucinating picking targets for the Pentagon, which is also possible.

01.03.2026 19:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The school was hit. Who hit the school is unknown. Misfired missle by Iran is also possible. Knowing the direction of the building damage would be useful.

Is damage on the north side of building? => failed missile launch by Iran.
Is damage on south side of building? => US strike.

01.03.2026 19:13 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

The direction of the damage, would help indicate from which direction the impact occurred. If on the north side of the building, then a failed missle launch by IGRC would be more likely than a US strike from the South or an Israeli strike from the West. Basic geography may help discern the truth.

01.03.2026 19:10 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

The school was hit. Who hit the school is unknown. Misfired missle by Iran is also possible. Unfortunately, none of the three governments has any credibility. Knowing the direction of the building damage would be useful. Are the photos looking east, with damage on north side of building?

01.03.2026 19:01 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

James Madison wrote "The constitution supposes, what the History of all Govts demonstrates, that the Executive is the branch of power most interested in war & most prone to it. <The Constituion> has accordingly with studied care, vested the question of war in the Legislature."

28.02.2026 16:28 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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ICE detained a Minnesota teen, labeled him an β€˜unaccompanied minor,’ and lost him The Trump administration is apprehending and designating immigrant kids as β€œunaccompanied,” even as their parents in the U.S. search for them.

Here is an example of a child which ICE "found" in Minnesota -- and abducted from his parents. Transported out of State and then lost.
www.startribune.com/how-ice-labe...

22.02.2026 17:29 πŸ‘ 13 πŸ” 8 πŸ’¬ 0 πŸ“Œ 3

When you put it like this, a $75 million bribe to Melania and gutting the Washington Post seems like a small price to pay.

22.02.2026 02:10 πŸ‘ 10725 πŸ” 4004 πŸ’¬ 255 πŸ“Œ 95
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New Documents Reveal a Controversial Vaccine Study's Unusual Path to CDC Approval A new investigation has found irregularities in the ethics review of a grant to study effects of a birth dose of hepatitis B vaccine in Guinea-Bissau.

More reporting on the unethical US gov funded hepatitis B vaccine trial in Guinea-Bissau. So many alarming aspects, among which CDC day-to-day operations is being run by a 24yo former DOGE with no public health training -- who scientifically approved this. www.rollingstone.com/politics/pol...

22.02.2026 04:25 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Living likes Kings and Queens while the peasants are the one’s paying taxes.

In Minneapolis, Whipple Federal building parking lot is full of vehicles, not being used; unmoved in last 18 hours since it snowed. We are paying for these new/rental vehicles. Waste.

19.02.2026 16:44 πŸ‘ 0 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

we couldn't use government funds to buy coffee (like, folgers ground coffee) when i worked on a CDC outbreak emergency response

19.02.2026 15:58 πŸ‘ 6465 πŸ” 1901 πŸ’¬ 147 πŸ“Œ 47
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In 2025, Trade Deficit in Goods Reached Record High

U.S. Imports Grew in 2025, as Trump’s Tariffs Reshuffled Global Trade www.nytimes.com/2026/02/19/b...

19.02.2026 16:41 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Seems the likely fall guy for finishing the destruction of CDC.

19.02.2026 13:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

If you’re decimating one public health agency, how hard can it be to decimate two?πŸ€¦πŸ»β€β™‚οΈπŸ€¦πŸ»β€β™‚οΈπŸ€¦πŸ»β€β™‚οΈ

19.02.2026 01:06 πŸ‘ 24 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0
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Listen closely to every word of this

19.02.2026 01:16 πŸ‘ 10649 πŸ” 4956 πŸ’¬ 355 πŸ“Œ 321

If ice wasn’t terrorizing their communities they would not have to wear masks. Their police do not have to wear mask. If ice treated people respectfully and lawfully they would not have to hide their faces.

16.02.2026 00:56 πŸ‘ 8833 πŸ” 1862 πŸ’¬ 350 πŸ“Œ 83
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ICE Agents Menaced Minnesota Protesters at Their Homes, Filings Say

ICE Agents Menaced Minnesota Protesters at Their Homes, Filings Say.
This might be why after ~2 months in Minneapolis, 3000+ ICE agents captured on average ~1.3 persons per agent (many of whom were legal residents, so likely <1 per agent) Waste of taxpayer $$$.
www.nytimes.com/2026/02/13/u...

14.02.2026 03:26 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Born in the USA  β€’ BRAVE NEW FILMS (BNF)
Born in the USA β€’ BRAVE NEW FILMS (BNF) YouTube video by Brave New Films

ICE routinely assaults and abducts US citizens.
Video montage of Americans abducted and kidnapped by ICE with song loaned by Springsteen. This is America. youtu.be/sNsQOdkTyAI

14.02.2026 02:46 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
"Moderna's CEO announced the company will no longer invest in new Phase 3 vaccine trials for infectious diseases: 'You cannot make a return on investment if you don't have access to the U.S. market. Vaccines for Epstein-Barr virus, herpes, and shingles have been shelved.”
9:12 AM
Feb 12, 2026
604.8K Views

"Moderna's CEO announced the company will no longer invest in new Phase 3 vaccine trials for infectious diseases: 'You cannot make a return on investment if you don't have access to the U.S. market. Vaccines for Epstein-Barr virus, herpes, and shingles have been shelved.” 9:12 AM Feb 12, 2026 604.8K Views

In terms of what cures are being lost:

- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease

13.02.2026 05:44 πŸ‘ 12541 πŸ” 6208 πŸ’¬ 444 πŸ“Œ 785
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AjornaDismissal021226

"Newly discovered evidence in this matter is materially inconsistent with the allegations in the Complaint Affidavit, filed on January 16, 2026, as ECF 1-1, as wellas the preliminary-hearing testimony that was based on information presented" (i.e. ICE lied) www.documentcloud.org/documents/26...

13.02.2026 01:57 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Update on the vicious plastic snow shovel and broom handle attack -- Federal charges dismissed.

Bullets went through the door striking the man with legal status, which contradict ICE agent firing at point blank range in self defense. (through a door?)

Was this BS all along? Yes.

13.02.2026 01:06 πŸ‘ 8 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
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$50,000

12.02.2026 20:51 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Minnesotans never surrendered.
If icy cold winters cannot defeat our spirit, ICE cannot.
If you have met NFL Vikings fans, resilience is part of who we are.

12.02.2026 18:41 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Border czar Tom Homan: Minnesota ICE surge to end Homan said the immigration enforcement operation will phase out in the next week.

#Minnesota ICE surge to end next week.
1st, 2nd, & 4th Amendment Rights trampled & 2 murders of US citizens.
>691 persons contesting their illegal detention with pending habeas corpus petitions in federal court.
Hundreds of Millions of Taxpayer dollars spent.

www.startribune.com/border-czar-...

12.02.2026 18:41 πŸ‘ 7 πŸ” 1 πŸ’¬ 1 πŸ“Œ 1
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Idaho families sue over immigration raid that swept up hundreds, including U.S. citizens β€” NBC News About 400 people, including children and U.S. citizens, were detained for four hours while they were denied food and water in the raid, according to the lawsuit.

More than 400 people, including hundreds of citizens, were β€œsorted” at gun point into racial and ethnic groups by 200 ICE agents who fired flash-bang grenades into cars with people inside, pointed guns at children & demanded their zip tied parents not comfort them. apple.news/Ausdx6kWtT0e...

12.02.2026 01:35 πŸ‘ 7620 πŸ” 3973 πŸ’¬ 239 πŸ“Œ 610