Justo P. Castaño 🔬🧬🧫 #SinCienciaNoHayFuturo's Avatar

Justo P. Castaño 🔬🧬🧫 #SinCienciaNoHayFuturo

@justocastano

Father, husband, scientist. Cell Biology Professor. IMIBIC - UCO Editor in Chief Endocrine Oncology @endocrineoncology.bsky.social Biomedical research: hormones & cancer, RNA splicing Pancreatic Cancer, Neuroendocrine tumors NETs 🦓 Always with a smile 😃

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Latest posts by Justo P. Castaño 🔬🧬🧫 #SinCienciaNoHayFuturo @justocastano

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@pedroveraoyp.bsky.social
Para la colección de titulares imposibles
No se veían esos peces desde la última vez que se acabó el mundo.
as.com/actualidad/a...

09.03.2026 22:22 👍 0 🔁 0 💬 0 📌 0
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Actualidad Universitaria - Las elecciones al Rectorado de la Universidad de Córdoba se celebrarán el 23 de abril El proceso incorporará voto electrónico y estará acompañado por una campaña informativa para fomentar la participación La Universidad de Córdoba celeb...

📅 La Universidad de Córdoba celebrará elecciones al Rectorado el próximo 23 de abril.

Participa y decide el futuro de tu universidad.

ℹ️ Toda la información 👇
www.uco.es/servicios/ac...

09.03.2026 11:49 👍 4 🔁 2 💬 0 📌 0
“Wait a minute! Isn’t anyone here a real sheep?”

“Wait a minute! Isn’t anyone here a real sheep?”

“Wait a minute! Isn’t anyone here a real sheep?”

09.03.2026 12:20 👍 1050 🔁 236 💬 0 📌 21
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📌AI contributes to efficiency in NEN research and clinical care but responsible use is needed – this was the overall conclusion at the INCA-ENETS Symposium 2026 on March 5th.
✅Read the news report on the INCA-ENETS session:
incalliance.org/inca-enets-s...
#LetsTalkAboutNETs #ENETS2026

09.03.2026 14:57 👍 1 🔁 1 💬 0 📌 0
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3D mapping of individual immune cells in the vicinity precancerous lesions in the human pancreas.

Maps obtained using the CODA workflow integrated with multiplex IF.

Paper accepted for publication in Cell Press Blue.

09.03.2026 12:24 👍 22 🔁 4 💬 0 📌 1
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La UCO inaugura la exposición de la XIII edición del Premio Bienal Internacional de Fotografía Contemporánea Pilar Citoler.

🖼️ La muestra reúne la obra de 15 artistas reconocidos y podrá visitarse en @ucocultura.bsky.social hasta el 12 de abril.

Más información 👇 www.uco.es/servicios/ac...

09.03.2026 17:54 👍 2 🔁 2 💬 0 📌 0
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GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

09.03.2026 18:01 👍 3 🔁 2 💬 0 📌 0
Endocrine Oncology logo. Patient-reported symptom and urgent healthcare use in neuroendocrine tumors. By Julie Hallet et al. 

Open Access logo.

Figure 3. Distribution of patients with urgent healthcare utilization (ED or hospitalization) within 14 days of ESAS assessment, stratified by ESAS score. Endocrine Oncology 6, 1; 10.1530/EO-25-0050.

Published by Bioscientifica logo.
80 Years 1946-2026 Society for Endocrinology logo.

Endocrine Oncology logo. Patient-reported symptom and urgent healthcare use in neuroendocrine tumors. By Julie Hallet et al. Open Access logo. Figure 3. Distribution of patients with urgent healthcare utilization (ED or hospitalization) within 14 days of ESAS assessment, stratified by ESAS score. Endocrine Oncology 6, 1; 10.1530/EO-25-0050. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

A new study by Julie Hallet et al. examines the association between patient-reported outcome measures (PROMs) & urgent healthcare use, with a view to inform better support strategies for patients diagnosed with neuroendocrine tumours (NETs).

🔓 Read the full article: doi.org/10.1530/EO-25-0050

09.03.2026 12:11 👍 1 🔁 1 💬 0 📌 0
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Descubren cómo el cáncer de páncreas se alía con nuestras neuronas para propagarse El hallazgo se encuadra dentro de la novedosa ‘neurociencia del cáncer’, que documenta cómo los tumores ‘secuestran’ nuestro sistema nervioso. El enfoque abre la puerta al uso de psicofármacos para ay...

Y el del cáncer de páncreas www.eldiario.es/sociedad/des...

08.03.2026 11:43 👍 5 🔁 2 💬 0 📌 0
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#WomanInScience

08.03.2026 09:12 👍 13 🔁 5 💬 1 📌 1
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Esto de @manueltowers.bsky.social en Diario Córdoba.

08.03.2026 09:41 👍 2 🔁 2 💬 0 📌 0
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La dulzura del león Durante la última década, el descrédito de la empatía y la compasión ha avanzado en paralelo al auge del odio

Una nueva corriente intenta arrojar la empatía al sótano tenebroso de todos los males. Tres autores norteamericanos han publicado recientemente ensayos que la describen como una emoción tóxica y suicida. Su descrédito avanza en paralelo al auge del odio.

elpais.com/opinion/2026...
@elpais.com

08.03.2026 09:51 👍 45 🔁 20 💬 2 📌 3
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Rocódromo para divulgar sobre ciencia??
Síiii! Y con mayor motivación al ser a favor de @contracancerinv.bsky.social
Con mujeres entusiastas y luchadoras de @LaRocadelFénix 🧗‍♂️

(Os dejo hilo para que veáis mis pinitos en escalada… 🤣🤦‍♀️)

08.03.2026 10:18 👍 1 🔁 1 💬 1 📌 0
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En el #8M, desde la Universidad de Córdoba reafirmamos nuestro compromiso con la #igualdad.

“Igualdad que forma, derechos que transforman”: hablar de igualdad en la universidad es educar en pensamiento crítico, promover valores democráticos y formar a quienes construirán el futuro.

¡Feliz 8M!💜

08.03.2026 10:38 👍 6 🔁 7 💬 0 📌 1
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With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

03.03.2026 08:58 👍 223 🔁 96 💬 5 📌 13
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🧬✏️ RNA Modifications Newsletter - March 2026 issue #9

RNA modifications are not static decorations, they are dynamic regulatory determinants. 🦠 The RNA modifications newsletter for March is out 👉https://rnamodifupdates.substack.com/p/rna-modifications-newsletter-march

02.03.2026 18:07 👍 6 🔁 2 💬 0 📌 0
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🚨🧬🚨

We're looking for a specialized Research Assistant to spearhead a project aimed at exploring new RNA therapeutics in diabetes and other metabolic disorders.

Junior or Senior, we're hoping to recruit a highly motivated and self-driven scientist interested in both basic and applied science. 🦄

02.03.2026 16:07 👍 7 🔁 11 💬 0 📌 0
Endocrine Oncology logo. Open-Access logo. 

To screen or not to screen: complexity of SDHA mutation management. By Einas Mohamed et al.

Figure 1
A structured clinical algorithm summarising the interpretation and management of SDHA variants. This flowchart integrates tumour phenotype, SDH immunohistochemistry (IHC) and germline findings to guide whether an SDHA variant should be considered ‘actionable’. In this context, an actionable SDHA variant refers to a germline or tumour finding that warrants clinical follow-up, including surveillance for SDH-related tumours and/or cascade testing for at-risk relatives. The algorithm begins with the identification of an SDHA-mutated tumour (e.g. GIST, phaeochromocytoma/paraganglioma or less typical SDH-associated tumours – such as RCC, neuroblastoma or pituitary adenoma)...Endocrine Oncology 6, 1; 10.1530/EO-25-0048

Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

Endocrine Oncology logo. Open-Access logo. To screen or not to screen: complexity of SDHA mutation management. By Einas Mohamed et al. Figure 1 A structured clinical algorithm summarising the interpretation and management of SDHA variants. This flowchart integrates tumour phenotype, SDH immunohistochemistry (IHC) and germline findings to guide whether an SDHA variant should be considered ‘actionable’. In this context, an actionable SDHA variant refers to a germline or tumour finding that warrants clinical follow-up, including surveillance for SDH-related tumours and/or cascade testing for at-risk relatives. The algorithm begins with the identification of an SDHA-mutated tumour (e.g. GIST, phaeochromocytoma/paraganglioma or less typical SDH-associated tumours – such as RCC, neuroblastoma or pituitary adenoma)...Endocrine Oncology 6, 1; 10.1530/EO-25-0048 Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

🧬 A new case report by Einas Mohamed et al. describes three carriers of germline SDHA variants, illustrating how clinical context is essential when deciding whether a variant should lead to surveillance or family testing.

🔗 Read the full report #OpenAccess: doi.org/10.1530/EO-25-0048

02.03.2026 10:44 👍 1 🔁 1 💬 0 📌 0
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RNA Splicing Lab - JOIN US Are you interested in investigating basic mechanisms in splicing regulation and gene expression? Our research group was launched in September 2024 and is hosted at the Institute of Molecular Infection...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

02.03.2026 15:44 👍 12 🔁 12 💬 0 📌 0
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Ultra-sensitive CAR T cells eliminate hard-to-treat tumours in mice Nature - A proof-of-concept study opens up an avenue for treating solid tumours that express low levels of a target antigen.

Ultra-sensitive CAR T cells eliminate hard-to-treat tumours in mice

A proof-of-concept study opens up an avenue for treating solid tumours that express low levels of a target antigen.

www.nature.com/artic...
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01.03.2026 21:39 👍 28 🔁 10 💬 1 📌 0
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A cancer cell videoed through a microscope. It has 3 nuclei (magenta). The powerhouse/overlords of the cell, mitochondria, are also shown (green). #CellBiology

01.03.2026 19:22 👍 24 🔁 3 💬 1 📌 0
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Irony just died www.theguardian.com/us-news/live...

01.03.2026 10:46 👍 6 🔁 4 💬 0 📌 0
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Imperialismo. En El Jueves

01.03.2026 12:10 👍 51 🔁 32 💬 0 📌 3
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Neuroendocrine Cancer: the blue dot needs to be bigger, but it must be the right message Ronny Allan - Living with Neuroendocrine Cancer Patient Advocacy

#NeuroendocrineCancer: the blue dot needs to be bigger, but it must be the right message ronnyallan.net/2024/06/30/n...

26.02.2026 10:42 👍 1 🔁 1 💬 0 📌 1

😂😂😂😂😂

28.02.2026 13:43 👍 0 🔁 0 💬 0 📌 0
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On #RareDiseaseDay, let’s unite research and patient voices to advance science, uncover mechanisms, and drive innovation.

Together, academia can shape equity in diagnosis and therapy.

For more #RareDiseaseResearch, click here: www.sciencedirect.com/journal/gene...

#GenesAndDiseases #Science

28.02.2026 13:39 👍 4 🔁 3 💬 1 📌 0
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La nutria europea sobrevive a la riada y continúa como un reclamo para los cordobeses en el Puente Romano Estos animales han vuelto a aparecer en el río Guadalquivir a su paso por Córdoba después de las grandes lluvias de finales de enero y gran parte de febrero

La nutria europea sobrevive a la riada y continúa como un reclamo para los cordobeses en el Puente Romano dozz.es/2gnc05

28.02.2026 11:50 👍 73 🔁 21 💬 3 📌 2
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Today is #RareDiseaseDay

Raising awareness means recognising the resilience of patients and their families, amplifying each other's voices and pushing for earlier diagnosis, better treatments and stronger support systems #BecauseHormonesMatter

👉 rarediseaseday.org

28.02.2026 11:42 👍 5 🔁 2 💬 0 📌 0
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This week's cover @thelancet.com

26.02.2026 23:48 👍 3118 🔁 1456 💬 44 📌 80
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And the Lancet's editorial that goes with it
www.thelancet.com/journals/lan...

26.02.2026 23:51 👍 417 🔁 161 💬 5 📌 10