Jonny Nixon-Abell

Last week, our team joined the @embo.org Workshop “Intracellular Mechanics & Organelle Mechanobiology” at @icfo.eu 🔬

Great talks, inspiring conversations, and fresh ideas for our projects! 💪

#Biology #Barcelona #EMBO

@adelaljord.bsky.social @pierre-bercier.bsky.social @crg.eu @prbb.org

Join us for a great session @asbmb.bsky.social annual meeting tomorrow. Our session starts at 9:30 am!

This is happening tomorrow! Looking forward to seeing all the #membranes enthusiasts on zoom!

Dziurdzik, Sridhar, Conibear et al. identify a conserved adaptor that recruits BLTP2-like proteins to ER–plasma membrane contacts by binding helical projections on their lipid transfer channel to maintain #lipid homeostasis. rupress.org/jcb/article/...

#MembraneContactSites #ER_literature

SF and Bay Area friends…at #bps2026 for the next five days…if you’re around and have time to catch up let me know 🙏😘

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

Congrats Pierre and Edward!

@biochemsoc.bsky.social

‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏

Massive congrats Alex and the lab!!!

Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...

😍😍😍. Congrats folks.!!

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Congrats Miranda!!!

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.

The german research foundation DFG will fund the new graduate school for

"Biomolecular Condensates: from physics to biological function" here in Dresden

This new graduate school is part of 18 new graduate schools funded by the DFG in germany!

Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...

Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...

Do you see any underlying driver/correlator for these numbers?

Number of canceled NIH grants by institution:

1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3

Source: taggs.hhs.gov/Content/Data...

Thanks Alex!

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!

Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.

@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.

www.nature.com/articles/s41...

Thank you 😊

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉

Interview with Jennifer Lippincott-Schwartz ABSTRACT. Jennifer Lippincott-Schwartz is a Senior Group Leader and Head of 4D Cellular Physiology at Howard Hughes Medical Institute's (HHMI) Janelia Research Campus. Throughout her career, Jennifer ...

Great interview with the always inspiring JLS - absolutely shaped so much about mine and so many others careers…

Thanks! 😊

Yep. Even with the starter packs ‘active’ 🤷

I have not - it’s another useful suggestion I should try. Thanks!

Then where are the less established folks haha?!? But yes your point about US is surely a factor.

Plenty of good starter packs…even so, I find I encounter far fewer papers that are relevant for my interests here…maybe this trick from @flodebarre.bsky.social will help though!

*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...

I had not seen this but this is great!! Thanks for the suggestion. Only downside is that it’s only papers from followers right. Although still a big improvement from my current feeds!