Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies - Drugs & Aging
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with cancer. Despite their prognostic value and negative effects on older patientsβ well-being, sarcopenia and cachexia are not routinely or adequately assessed and managed in clinical oncology practice. However, efforts to recognize and manage sarcopenia and cachexia at diagnosis and during follow-up may have beneficial effects on muscle mass, physical function, and quality of life among older adults with cancer, although evidence on long-term clinical outcomes in response to targeted interventions has yet to be established. This comprehensive review attempts to (i) delineate the differences in the pathophysiology and clinical manifestations between sarcopenia and cachexia, (ii) clarify how sarcopenia and cachexia are defined in the geriatric oncology literature, (iii) describe methods for assessing sarcopenia and cachexia in clinical practice, (iv) review the prognostic value of sarcopenia and cachexia among older patients, particularly those undergoing systemic cancer treatment, and (v) discuss evidence-based strategies aimed at managing sarcopenia and cachexia for older adults with cancer.
In this review, we describe the pathophysiology of sarcopenia and cachexia, explore their definitions in the context of geriatric oncology, and examine assessment methods used in clinical practice. Great job Makis.
link.springer.com/article/10.1...
09.10.2025 01:27
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Exposure of resting #Tcells to physiologically relevant #lactate concentrations is shown to increase #mitochondria #respiration of resting T-cells in culture, suggesting that vigorous #exercise may prime immune cell function.
doi.org/10.14814/phy...
#Physiology #ImmuneSystem
25.07.2025 09:02
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I recently stumbled upon the gt package for R programming, a real game-changer for anyone looking to elevate their table game!
Developed by Richard Iannone and colleagues, it simplifies table creation.
Package documentation: https://gt.rstudio.com/
More: http://eepurl.com/gH6myT
#data #statistics
16.01.2025 10:38
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Congratulations Brandon
08.01.2025 04:03
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Super excited to have installed the Technavance Bilateral Knee Extension Ergometer. Bengt Saltin would be proud. @lsukinesiology.bsky.social
05.12.2024 16:39
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This will enhance our understanding of how exercise improves lipolytic function to bring about beneficial effects, offering new insights into potential therapeutic avenues for promoting health and alleviating diseases.
www.sciencedirect.com/science/arti...
29.11.2024 15:43
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#Lactate #metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms
jneuroinflammation.biomedcentral.com/articles/10....
29.11.2024 14:56
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A snip of my profile. Banner image incldes Arendt, Durkheim, Fanon and others drawn rouglys on eggs in Black and White. Profile picture is me in front of some autumn leaves.
Key descriptive text identifies me as a criminologist working on atrocity crime.
At the bottom, highlighted by a big red arrow is my ORCID ID: 0000-0002-7463-1302
A snip from my ORCID profile page - at the left is a list of institutional and other links to social media, including one to Bluesky, highlighted by a big red arrow.
Academics wanting to 'verify' their Bluesky profile as genuine might give an ORCID identifier in their profile and link back to their Bluesky profile from ORCID.
#AcademicSky
21.11.2024 09:13
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Check out our database of 47 POSTDOCTORAL fellowships in cancer/oncology.
For each fellowship, we provide a brief description, link to opportunity, deadline, and eligibility criteria (e.g. citizenship).
Download this database here (Excel file): research.jhu.edu/rdt/funding-...
Good luck!
24.11.2024 14:20
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Nathan can you add me to your starter pack?
24.11.2024 15:12
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Where is the βMitochondria is the powerhouse of the cellβ starter pack
19.11.2024 16:25
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We are recruiting an Assistant Professor with expertise in biotechnology, biosensing, or Ai in the LSU School of Kinesiology.
lsu.wd1.myworkdayjobs.com/LSU/job/H-P-...
If you have any questions please feel free to reach out.
15.11.2024 23:09
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Count me in too.
17.11.2024 01:38
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Summiting Mount Everest in #deuterium depleting nutritional #ketosis without supplemental oxygen
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www.sciencedirect.com/science/arti...
16.11.2024 11:29
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Impaired branched chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux
www.sciencedirect.com/science/arti...
16.11.2024 11:21
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We are recruiting an Assistant Professor with expertise in biotechnology, biosensing, or Ai in the LSU School of Kinesiology.
lsu.wd1.myworkdayjobs.com/LSU/job/H-P-...
If you have any questions please feel free to reach out.
15.11.2024 23:09
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New from Cold Spring Harbor Press. Available in December, 2024, just in time for the holidays! -RJD
15.11.2024 19:06
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a bald man in a blue suit is making a funny face and pointing at something .
ALT: a bald man in a blue suit is making a funny face and pointing at something .
People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.
13.11.2024 19:24
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