Jeffrey Huang

Meghan's handle... @meghanrb.bsky.social

If you are @sfn.org #SfN25 #SanDiego, come by and see posters from:

*George Melchor @drgliaguy.bsky.social. PSTR166.14; Board J12; Abstract 14751
*Meghan Bullard. PSTR165.07; Board: H12; Abstract: 7512

Session: Multiple Sclerosis and Neurodegeneration
Monday, Nov 17, 8AM-12PM
SDCC Halls B-H
😀

Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination - Journal of Neuroinflammation Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune cell-driven demyelination and progressive neurodegeneration. Senescent cells (SCs)...

Very happy to share that Zeeba @zeebamehrin.bsky.social's work on cellular senescence in EAE is now published in J Neuroinflammation! Congratulations, Zeeba, on this informative study! 😀https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03425-3

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...

Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...

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Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...

‪Congratulations Phil @philgrossphd.bsky.social and a huge thank you to all the lab members and collaborators for their contributions to our project on the role of senescence in remyelination, which has now been published in @naturecomms.bsky.social! 😀 www.nature.com/articles/s41...

Cool paper. Congrats Ethan and team!

Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...

New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠

www.nature.com/articles/s41...

Thx Ethan! 😀

Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1

The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination Protein kinase C modulation with bryostatin-1 enables innate immune cells in the central nervous system to promote myelin repair and regeneration.

Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...

Congratulations to Phil, George, and Jingwen @PhilgrossPhD @thegliaguy @Jingwen_SMyelin on your doctoral hooding and graduation from @Georgetown! It’s been an incredible journey with you over the years. I’m so proud of your accomplishments.

Very proud that George Mechor @thegliaguy successfully defended his PhD thesis on the analysis of #remyelination via single nuc RNA-seq. We've learned that single cell studies are informative but an exhausting endeavor 😀. Congratulations Dr. Melchor on your remarkable

https://www.bbc.co.uk/sounds/play/w3ct5xh0

Are we close to a breakthrough for Multiple Sclerosis?Thanks @bbctanyabeckett @BBCTheInquiry for this informative program and the opportunity to discuss MS treatment and repair strategies with @tim_coetzee @TZiemssen @CShannonLowe. #MS #remyelination...

Very excited that Phil Gross @PSGrossScience @georgetown #IPN #GUBiology has successfully defended his PhD thesis on the role of cellular senescence in CNS remyelination. Next stop a postdoc at the NIH. Congratulations Dr. Gross! 🎉🎉🎉🍾🍾🍾

Ancient DNA helps trace multiple sclerosis origins in European descendants https://www.washingtonpost.com/science/2024/01/10/ancient-dna-multiple-sclerosis-european-ancestry/

https://www.nature.com/articles/s41536-023-00345-9

Congratulations to @Jingwen_SMyelin on the publication of her manuscript showing the effect of myeloid cell derived aromatic alpha-keto acids (AKAs) in remyelination. Big thanks to @thegliaguy, @Meng2Fu, @PavanBhargavaMD and everyone who contributed!...

Very proud that my brilliant grad student @Jingwen_SMyelin successfully defended her PhD thesis today on the effect of aromatic amino acid metabolism in #remyelination. Congratulations Dr. Hu! 😀 #MultipleSclerosis #GUBiology @Georgetown

Dr. Anthony Fauci To Join Georgetown Faculty as Distinguished University Professor - Georgetown University https://www.georgetown.edu/news/dr-anthony-fauci-to-join-georgetown-faculty-as-distinguished-university-professor/

Proud of @lauren_rosko for receiving the @ASNeurochem Marian Kies Award for outstanding graduate research at #ASN2023. Congratulations Lauren!!! 😀

And thanks to all the awesome co-authors @Zeebamehrin, @JingwenHu10, @thegliaguy, and the wonderful undergraduate researchers in our lab @Georgetown for their contribution, and thanks to the reviewers and editors for their helpful comments on our study.

https://www.jneurosci.org/content/43/7/1143

Excited to see @lauren_rosko's PhD work published in @SfNJournals. Cerebral creatine deficiency syndrome is a rare disease that affects CNS development. Lauren found that oligodendrocytes are the major producers of creatine in adult CNS. Congratulations!...

@thegliaguy @PSGrossScience @Zeebamehrin @MiaCozart3 @Georgetown

If you are at #SfN2022 and interested in MS, remyelination, senescence, and immunometabolism, checkout my grad students posters
George Melchor 11/12 Diversity poster session 6:30-8:30pm
Phillip Gross 11/14 8-9am #G14
Mia Cozart 11/14 11-12am #B29
Zeeba Manavi 11/16 10-11am #N14

Had a great time at the inspiring ⁦@mssociety⁩ Ambassadors Ball w my awesome grad students :) ⁦@thegliaguy⁩ ⁦@Zeebamehrin⁩ ⁦⁦@PSGrossScience⁩ ⁦@MiaCozart3⁩ ⁦⁦@Georgetown⁩ #EndMS

https://www.customink.com/fundraising/uvalde-strong-fundraiser

Dear Twitter friends, George @thegliaguy, who is a PhD student in my lab, has lost his niece in the recent shooting in Uvalde, TX. To support the families of Robb Elementary at Uvalde, you can buy a t-shirt and donate to this fundraiser. Thx....