Please spread this far and wide, as stories don't get much bigger than this. When the government blocks even the intelligence services from telling us we're heading for environmental catastrophe, you know we have a problem. A very big problem.
Thank you.
www.theguardian.com/commentisfre...
Adam Kampff prioritized spreading knowledge over publishing flashy papers in prestigious journals, but colleagues say his mark on neuroscience was undeniable. The researcher and educator passed away on 9 December.
By Lauren Schneider
www.thetransmitter.org/systems-neur...
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
I doubt a new party is going to get 20% of the vote in any reasonable time frame. Certainly not by the next election, which it what we need to stop Farage.
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
🔬👨💻📰 #SReD is out!
Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️
Brainchild of @afonsomendes92.bsky.social and adventure w @christlet.bsky.social lab + friends.
Check: www.nature.com/articles/s41...
The first article begins with a short history of the approach
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
A huge day for mapping in life science!
—the mammalian brain, most extensive yet (10 papers @nature.com journals)
nature.com/articles/s41...
@alleninstitute.bsky.social
—a comprehensive map of the human cell->sub-cellular
nature.com/articles/s41...
—complete ape genomes
nature.com/articles/s41...
How does the brain work?
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
Today @nytscience.bsky.social on the microplastics (=5 bottle caps) in our brain, the recent @naturemedicine.bsky.social paper
gift link www.nytimes.com/2025/04/08/w...
This won't kill it, it will just hurt people with lower incomes. It needs to be carefully dismantled by enlightened governments. We are a bit short on those however.
Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.
elifesciences.org/reviewed-pre...
Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D!
Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...
I would encourage anyone asked to referee for a Royal Society journal, to very vocally follow Michael’s example. 🧪 ⚛️ 🔭
I've got a kite with 800 m of line and I have used most of it on one occasion. So it must have been at 200 or 300 m.
Vsauce puts all this well:
A practical guide for anyone using multiphoton microscopes: Assess your system performance with quick, affordable tests - ensuring reliable, standardised data across labs.
Out now in @natprot.bsky.social ⬇️
www.nature.com/articles/s41...
When I first joined here I remember there being a lot of posts about how the 'culture' of bluesky was to block liberally and starve the trolls.
I just hope people are still doing that!
That was a fun project! Thanks to Rob Lees, Adam Packer, and all the co-authors for inviting me to participate.
rdcu.be/edQXi
Everyone who is able should be doing this. And growing as much of their own food as they can, and saving seed
But individuals can only do so much, and millions don't have the means to stockpile or grow
The government should be making appropriate plans NOW
www.theguardian.com/commentisfre...
Many forms of Long Covid: Long Covid is a multisystemic disease with sequelae that affect almost all organ systems. Various putative mechanisms that underlie these sequelae are not mutually exclusive and may explain the myriad health effects seen in Long Covid. Therapeutics that target these pathways, such as antivirals, anti-inflammatory agents, microbiome restoration, and anticoagulant drugs, may ameliorate symptoms.
A #SciencePerspective by @zalaly.bsky.social and @erictopol.bsky.social identifies key issues that need to be prioritized in the study of #LongCovid.
Learn more on #LongCovidAwarenessDay: scim.ag/3XKbds3
Thanks. It was great to host you all.
I returned two objectives to Nikon with damaged front elements. It took several months to get them back and cost was about 50% of new. A different time I returned an objective that seemingly spontaneously started to produce a horrible PSF. Took many months but was never charged.
Three images with figure excerpts from the paper, highlighting 1) single-spike detection analysis, 2) autocalibration analysis, and 3) non-linearity of calcium-to-fluorescence transfer functions and their effect on the reporting of complex spiking events.
Are you using GCaMP8 or are planning to switch from GCaMP6? Then check out this new preprint from our lab! www.biorxiv.org/content/10.1...
- Calcium imaging
- GCaMP8 vs. GCaMP6
- Spike inference
- Imaging + ephys ground truth
With F. Helmchen, K. Svoboda, M. Rozsa & X. Fang.
Please see our manuscript on a digital 3D bird brain atlas of a migratory and magnetoreceptive species (Eurasian blackcap) online now 🦅🧲🧠: biorxiv.org/content/10.1...
See also short thread👇
I was loosely involved in a study of the effects of space flight on kidney function. Punchline is that astronauts might make it to Mars but the radiation means they would likely need dialysis on the return. www.eurekalert.org/news-release...
It's a dangerous game. It starts ok then you end planning your holidays based on light pollution maps. Then you want even darker skies and you end up in the desert surrounded by hundreds of tarantulas.
I also have a telescope. Or two. Or three... More to chat about on the 14th!
