Monocyte-derived IL-10 drives sex differences in pain duration Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

Sex differences in pain duration
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...

Professorship awarded to Mina Gouti Mina Gouti has been awarded a professorship at Charité – Universitätsmedizin Berlin. The appointment will strengthen her pioneering organoid research at the Max Delbrück Center and deepen collaboratio...

Congratulations to Mina Gouti on her promotion to Professor

www.mdc-berlin.de/news/news/pr...

Big congrats to the entire Kaessmann lab for this spectacular achievement and beautiful insights. It was a great honour to contribute to this study and to host Ioannis in our lab, an absolutely brilliant scientist. Evolution of genomic enhancers controlling neuronal cell types is just too cool..

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

This is figure 1, which shows AlphaGenome model architecture, training regimes and comprehensive evaluation performance.

A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪

Interpretation, extrapolation and perturbation of single cells Nature Reviews Genetics, Published online: 02 January 2026; doi:10.1038/s41576-025-00920-4Causal and mechanistic modelling strategies, which aim to infer cause–effect relationships, provide insights into cellular responses to perturbations. The authors review computational approaches that harness machine learning and single-cell data to advance our understanding of cellular heterogeneity and causal mechanisms in biological systems.

FYI: New online! Interpretation, extrapolation and perturbation of single cells

🧬 Only one month until the 2nd meeting on early embryogenesis & epigenetics. #Embryo2026

Barbara Treutlein (@ethz.ch) will speak about her work reconstructing human brain development with organoids and single-cell technologies!

More information: www.molgen.mpg.de/embryo2026

An expanded registry of candidate cis-regulatory elements - Nature The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types...

Our paper on the newest version of the Registry of candidate cis-Regulatory Elements (cCREs) is out 🧬

Huge thanks to the many collaborators, experimentalists, analysts and software developers who made this work possible — truly a team effort!

A "meme-torial" of the science is coming soon 👀

Now out: The new ENCODE registry of candidate cis-regulatory elements (🐭/👶)

Major consortium effort, led by @moorejille.bsky.social - stay tuned for her "meme-torial"

www.nature.com/articles/s41...

@berkeleylab.lbl.gov @biosci.lbl.gov

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

Meanwhile, in countries that still do scientific research and medicine.....

www.bbc.com/news/article...

Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...

Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.

Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...

If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow

"We thank the reviewers for their helpful suggestions"

IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...

Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...

📢 Speaker showcase for our 2nd Meeting #Embryo2026 🧬Vincent Pasque @pasquelab.bsky.social from @kuleuvenuniversity.bsky.social will speak about his work on modelling early human embryogenesis with naïve pluripotent stem cells.
More information👇
www.molgen.mpg.de/embryo2026

We were very happy to welcome this amazing group of early-career researchers as part of the @Falling Walls Science Summit in Berlin! Special thanks to @annaamonaco.bsky.social (Mundlos Lab) and @matthewkraushar.bsky.social for hosting the group and providing an in-depth tour of their labs!

Thrilled to start my Group Leader adventure with these and other great scientists!

Three new research groups joining the MPIMG

We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...

🧬📢 We look forward to welcoming Jacob Hanna from the Weizmann Institute of Science as part of our speaker lineup for the #Embryo2026 meeting!

More information 👇
www.molgen.mpg.de/embryo2026

Redefining cellular reprogramming with advanced genomic technologies Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.

New online! Redefining cellular reprogramming with advanced genomic technologies

🗓️Abstract Deadline Extended
to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org

The IMPRS-BAC call is open until January! Interested in applying to the graduate school? Here are ten tips for a successfull application! ⬇

Check out our projects and apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...

#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de

Redefining cellular reprogramming with advanced genomic technologies Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.

ICYMI: New online! Redefining cellular reprogramming with advanced genomic technologies

SharePic for the contribution of Eileen Furlong from EMBL for the 2nd Meeting on Early embryogenesis & epigenetics organized by the Max Planck Institute for Molecular Genetics in Berlin with support by the Weizmann Institute for Science. The SharePic features the portrait of Eileen and the title of her contritbution "Genome regulation during embryogenesis: Going loopy about enhancer regulation".

📢🧬 Next in the speaker line-up for #Embryo2026 is @eileen-furlong.bsky.social from @embl.org who will present her research on

"Genome regulation during embryogenesis: Going loopy about enhancer regulation"

Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute

Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...

Delighted to share our new study in @natcellbio.nature.com showing that the unique epigenetic landscape of ecDNA can enable the oncogenic enhancer activation of transposable elements! This was a great collaboration with @katerinakraft.bsky.social and @sedonamurphy.bsky.social. tinyurl.com/mwfbu4w4

📢Speaker showcase for our 2nd Meeting #Embryo2026 🧬

@jamesbriscoe.bsky.social from @crick.ac.uk will speak on

The Dynamics of Neural Tube Formation

More information on www.molgen.mpg.de/embryo2026

Structural variants in the 3D genome as drivers of disease Nature Reviews Genetics - Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical...

Our featured article: Structural variants in the 3D genome as drivers of disease - Review by Varun K. A. Sreenivasan, Verónica Yumiceba & Malte Spielmann go.nature.com/4oiPdPQ
Free to read here: rdcu.be/eu0KR

Our November 2025 issue is now live: go.nature.com/4hlXnVx
Topics include: the impact of structural variation on the 3D genome in disease; single-cell DNA sequencing of somatic mutations; the role of transcription compartments in gene regulation; synonymous mutations and their consequences