Anna Malkowska

JCS Cover: The image shows human induced pluripotent stem cell-derived neurons immunostained for LAMP2 (red) and the neuronal marker TUJ1 (blue) and expressing LAMP1–EGFP (green; detected by anti-GFP immunostaining). LAMP1 and LAMP2 are members of the same protein family and are commonly used interchangeably to label lysosome-like organelles. However, new findings indicate that they localise to functionally distinct organelles, and this image highlights the heterogeneity of the neuronal endolysosomal system. See article by R. Abouward et al. (jcs264466).

Issue 3 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

On the cover: hiPSC-derived neurons labelled with TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
journals.biologists.com/jcs/article/...

Congrats @reemward.bsky.social on the cover!!!

Thank you!!!

Neural stem cell quiescence is actively maintained by the epigenome Homeostasis of the nervous system is maintained by a population of resident neural stem cells (NSCs) retained in a state of reversible cell-cycle arre…

PhD paper finally out! Neural stem cell quiescence is actively maintained by the epigenome: www.sciencedirect.com/science/arti...

Thank you so much, Maire! 💕

Thank you!

Neural stem cell quiescence is actively maintained by the epigenome Homeostasis and repair of the nervous system is maintained by a population of resident neural stem cells (NSCs) retained in a state of reversible cell cycle arrest called quiescence. quiescent NSCs ca...

Happy to share a preprint of my PhD work! We created a chromatin state model for quiescent and proliferating neural stem cells in Drosophila and found that quiescent cells gain active chromatin to support stem cell functions.
www.biorxiv.org/content/10.1...

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...

Ready to push some flies

Quiescent neural stem cells transiently become 'neurons' to coordinate reactivation Reactivation of quiescent neural stem cells (qNSCs) is a coordinated process that generates new neurons and glia. Here, we show that during development reactivation follows a hierarchical sequence, wh...

✨New✨ Brand lab preprint - Quiescent neural stem cells adopt a transient 'stem cell-neuron' identity to coordinate their reactivation across the CNS. We've been discussing the neuron-like traits of quiescent NSCs for years, so it's been wonderful to see Laura and Jocelyn uncover these mechanisms! ⚡