Arne Elofsson

Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...

Merlin: a computed tomography vision–language foundation model and dataset - Nature Merlin, a vision–language foundation model trained on a large dataset of paired CT scans, patient record data and radiology reports, demonstrates strong performance across model architectures, di...

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Hilarious. The Republican Party:

VR also did that (at least a few years ago). However, the "middle group" was quite small, I think.

The secret of squeaky basketball shoes idp.nature.com/authorize?re...

Systematic analyses of lipid mobilization by human lipid transfer proteins - Nature Systematic characterization of human lipid transfer proteins in complex with their lipid partners reveals the relevance of these interactions for lipid metabolism, identifies mechanisms that cont...

www.nature.com/articles/s41...

The surprising science of squeaky sneakers The mystery of why soft shoes squeak on hard floors may be solved, according to new research

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COVID’s origins: what we do and don’t know Researchers summarize key insights from the world’s first comprehensive investigation into how a pandemic started.

COVID’s origins: what we do and don’t know idp.nature.com/authorize?re...

How big is the ‘motherhood penalty’? In Denmark, it adds up to $120,000 An analysis documents the cumulative income hit mothers incur — as well as the extent to which state aid can offset the loss.

www.nature.com/articles/d41...

The Trump Administration Is Ending Aid That It Says Saves Lives The State Department will let lifesaving projects expire because “there is no strong nexus between the humanitarian response and U.S. national interests,” according to an internal email.

Quietly, the Trump administration is now ending even the life-saving aid that they had promised would be preserved

Reporting from @hana-kiros.bsky.social

www.theatlantic.com/health/2026/...

"silly"
and no, it's not a war over territory

I'd assume that the Diffusion model in AF3 had learned that distribution

I guess it depends on how good AF is to predict backbone dihedrals before chi angles.

seems interesting www.biorxiv.org/content/10.6...

Accurate predictions of disordered protein ensembles with STARLING - Nature The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.

www.nature.com/articles/s41...

‘An AlphaFold 4’ – scientists marvel at DeepMind drug spin-off’s exclusive new AI Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.

“It’s a major advance, on the scale of an AlphaFold4. The problem, of course, is that we know nothing of the details.”

Isomorphic Lab’s proprietary drug-discovery model is a major advance
go.nature.com/3Mm2ZnQ

My linocut portrait of Marie Maynard Daly in purples (she’s a young smiling Black woman, wearing earrings, a necklace and a dress, looking at the viewer over her shoulder). Above her to the right is an anatomical heart with a blowout diagram in a circle of a clogged artery and the cholesterol molecule all in red. Next to her on the left in blue are the molecules of the bases which make up DNA and a diagram of a human cell.

#BlackHistoryMonth is a great time to celebrate #biochemist Marie Maynard Daly (1921-2003), 1st Black woman to earn a PhD in #chemistry in the US! 🧪🐡👩🏿‍🔬 #histsci She made important research contributions to our understanding of the biochemisty of the cell nucleus & cardiovascular issues & the 🧵

The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold - Isomorphic Labs Today, we are excited to share an update on our progress towards a new frontier of drug design. We have unlocked a new paradigm of predictive accuracy in understanding our biomolecular world, allowing...

Isomorphic Labs said IsoDDE, a drug-design system, more than doubles AlphaFold 3's accuracy on the Runs N Poses benchmark and outperforms AlphaFold 3 by 2.3x on antibody–antigen DockQ>0.8 tests.

Really, no information on what is novel. Training, model?

Isomorphic Labs Drug Design Engine (IsoDDE), a unified computational drug-design system

Announcement:
www.isomorphiclabs.com/articles/the...

Report:
storage.googleapis.com/isomorphicla...

What has changed in 20 years

Comic. [2x2 chart. Top left quadrant: seem like dinosaurs x are dinosaurs. Silhouettes of dinosaurs stegosaurus, triceratops, tyrannosaurus, velociraptor, and long-neck dinosaur. Top right quadrant: seem like dinosaurs x are not dinosaurs. Silhouettes of mosasaur, quetzalcoatlus, dimetrodon, plesiosaur, and pteranodon. Bottom left quadrant: don’t seem like dinosaurs x are dinosaurs. Silhouettes of penguin, egret, ostrich, pigeon, falcon. Bottom right: don’t seem like dinosaurs x are not dinosaurs. Silhouettes of squirrel, stapler, plant, person, and bicycle.]

Dinosaurs And Non-Dinosaurs

xkcd.com/3204/

New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments

www.biorxiv.org/content/10.6...

Briefing Chat: 'External lungs' keep man alive for 48 hours until transplant Hear the biggest stories from the world of science | 06 February 2026

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Vibe Coding Omics Data Analysis Applications Building custom data analysis platforms has traditionally required extensive software engineering expertise, limiting access for many researchers. Here, I demonstrate that modern large language models...

I am remiss for pointing out that Jesse @j-my-sci.bsky.social highlights sharing, explainable code, and testing in his paper. These weren’t points he missed, just things I wanted to expound on or highlight (including my TopHat2 typo).

pubs.acs.org/doi/10.1021/...

8/7

I just released v1.4 + v1.5 of "mkdocs-quiz" this week with some fun new features:

✍️ Fill-in-the-blank quizzes (not just multiple choice)
💾 QTI export for Canvas/Blackboard/Moodle
✨ Interactive terminal CLI quiz runner

github.com/ewels/mkdocs-quiz

A benchmark of expert-level academic questions to assess AI capabilities - Nature Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

www.nature.com/articles/s41...

Multimodal learning with next-token prediction for large multimodal models - Nature Emu3 enables large-scale text, image and video learning based solely on next-token prediction, matching the generation and perception performance of task-specific methods, with implications for the de...

www.nature.com/articles/s41...

4-panel comic. (1) [Person 1 approaches Person 2 (with ponytail), sitting at desk with a laptop.] PERSON 1: Do you have an extension cord with prongs at both ends? Can I borrow it? PERSON 2: *NO!!!* (2) [Person 2 throwing up her hands.] PERSON 2: No one should *EVER* buy or make those! They start fires, destroy equipment, and risk electrocuting you or grid workers! PERSON 1: OK, OK, I get it. (3) PERSON 1: Can I just borrow a regular cord, then? PERSON 2: Sure. Here. [Person 2 hands cord to Person 1.] PERSON 1: The prongs aren’t important. I just thought they’d help anchor it to the wall. PERSON 2: Wait, what are you– (4) PERSON 1: I need it to help hold up the top half of the reflector for this plutonium core that I’m– PERSON 2: *AAAAAAAA!!!!* [Person 2 screams with hands on head as Person 1 walks away.]

Double-Pronged Extension Cord

xkcd.com/3198/

Nobody has caused more damage to the US in one single year than Donald Trump:
1. He has abolished the rule of law.
2. He has made the US more corrupt to his benefit than ever.
3. He promotes extreme crony capitalism.
4. He has sharply cut science financing. /1