Ran Blekhman's Avatar

Ran Blekhman

@blekhman

Professor of Medicine at the University of Chicago. Decoding the human microbiome. http://BlekhmanLab.org

4,978
Followers
263
Following
283
Posts
11.09.2023
Joined
Posts Following

Latest posts by Ran Blekhman @blekhman

Professorship in population genetics in the field of evolutionary anthropology and medicine (W2) Faculties & Facilities

Leipzig U and the MPI for Evolutionary Anthropology (MPI-EVA) have an open faculty position (W2) in evolutionary population genetics! This position is tenured and comes with generous core funding. We are eager to welcome a new colleague! Deadline March 11.
www.uni-leipzig.de/en/newsdetai...

05.03.2026 16:38 πŸ‘ 53 πŸ” 84 πŸ’¬ 0 πŸ“Œ 0

I once did 2 study sections week after week. Never again

05.03.2026 19:56 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Got 5 NIH study section invitations in one week. For 5 different panels in May. Never happened before. Not sure what's going on but feels like there is a serious strain on the system.

04.03.2026 20:04 πŸ‘ 13 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0
Preview
AI Keeps Failing at Microbiome Prediction Why simple models keep winning, where deep learning still shines, and where the field is headed

AI has huge promise for genomics -- but it has consistently failed at microbiome-based prediction.

My new post on why simple models keep winning, where deep learning actually earns its place, and where the field is headed

blekhman.substack.com/p/ai-keeps-f...

02.03.2026 00:59 πŸ‘ 47 πŸ” 28 πŸ’¬ 0 πŸ“Œ 0
Post image

Last week I took one of my favorite Chicago photos of all time. This city is LONG

20.02.2026 14:16 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials Prebiotic and probiotic interventions can induce therapeutically relevant shifts in the human microbiome, but their effects are variable across individuals. This study shows that metabolic models can ...

Our latest is out today in @plosbiology.org:

"Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials"

@isbscience.org @uwbioe.bsky.social @uwgenome.bsky.social

doi.org/10.1371/jour...

19.02.2026 19:59 πŸ‘ 40 πŸ” 19 πŸ’¬ 2 πŸ“Œ 0

Yes, they can hallucinate papers that don't exist, discuss results that seem to be imaginary, and can be confusing and inconsistent. But talking to tenured professors may still be helpful

14.01.2025 22:30 πŸ‘ 745 πŸ” 166 πŸ’¬ 14 πŸ“Œ 9

Terrible. Still need to see a bit more of the timeline, but based on this trend I don't see how the NIH will fund even 10,000 new awards this fiscal year. Maybe closer to 8000

18.02.2026 02:22 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

In 1800 (not that long ago!) the average life expectancy was ~30 years.

17.02.2026 19:22 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Same here - straight forward, took about 15 minutes. Could be because I've had experience with using this for an NSF biosketch some years ago?

16.02.2026 21:49 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
So your paper was reviewed by AI. Now what? A practical guide to handling the new reality of AI-generated reviews

I've been hearing from more and more people who received peer reviews that were clearly written by AI. It's frustrating, and no one knows what to do. I have some thoughts.

blekhman.substack.com/p/so-your-pa...

15.02.2026 00:48 πŸ‘ 8 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Post image

Good morning from Chicago

14.02.2026 19:10 πŸ‘ 90 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

The problem is proving with certainty that the review was AI generated. I guess it is up to the editor to decide what to do. In my experience, it might be fastest to just respond to the review as is (these AI comments can actually be easy to address/refute)

13.02.2026 19:08 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Personal experience with AI-generated peer reviews: a case study While some recent studies have looked at large language model (LLM) use in peer review at the corpus level, to date there have been few examinations of instances of AI-generated reviews in their social context. The goal of this first-person account ...

A different field, but relevant reading: pmc.ncbi.nlm.nih.gov/articles/PMC...

13.02.2026 18:54 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.

12.02.2026 19:18 πŸ‘ 53 πŸ” 95 πŸ’¬ 0 πŸ“Œ 0

As a research university, grad students are the driving force of your research mission. They generate the data, papers, and prelim results for future grants. You will be less competitive when funding recovers (and it will). You are also creating a pipeline gap that will take 5 years to rebuild

12.02.2026 19:03 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

This is also bad for labs: there are many PIs who have secured funding but can't find students. Research programs and careers will stall, not from lack of money but lack of people

12.02.2026 18:57 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

This is bad because excellent students who would thrive in research careers will get shut out. Many candidates won't reapply next year, and we will lose them permanently to non-research fields

12.02.2026 18:56 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

We should talk more about the graduate admissions crisis that's taking shape in the US.

Talking to colleagues across universities, many graduate programs are slashing admission numbers and reducing class sizes substantially for the upcoming academic year.

This is shortsighted

12.02.2026 18:54 πŸ‘ 11 πŸ” 2 πŸ’¬ 1 πŸ“Œ 1

if you're in line to sack drake maye, STAY IN LINE

09.02.2026 02:15 πŸ‘ 9 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Work led by Katja Della Libera and Beth Adamowicz in my lab, in collaboration with Francesca Luca's lab at UChicago

04.02.2026 14:22 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Post image

Our new paper, where we use metabolic modeling to show Fusobacterium grows faster in colorectal tumor vs normal tissue microenvironments, and use computational + experimental approach to find specific metabolic pathways driving host-microbiome interactions in cancer

www.biorxiv.org/content/10.6...

04.02.2026 14:17 πŸ‘ 15 πŸ” 5 πŸ’¬ 2 πŸ“Œ 0

I can't talk about the details of the specific case you're describing, of course. But I think it's common that as a reviewer, one can find flaws in any paper, and list improvements that will make any paper "stronger". But the authors can disagree, and have the right to decide not do the work.

03.02.2026 18:56 πŸ‘ 1 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0

This is not heartbreaking. Keep in mind that the authors perspective: they probably disagree that their paper "needs a lot of work". Instead they find another journal (and another set of reviewers) that agree with them, and save months of expensive, time consuming, unnecessary work.

03.02.2026 00:25 πŸ‘ 5 πŸ” 0 πŸ’¬ 4 πŸ“Œ 0

Work led by @pamferretti.bsky.social, with collaborators including Mattea Allert, Kelsey Johnson, Cheryl Gale, Ellen Demerath, Frank Albert, and David Fields.

See Pamela's thread below:

bsky.app/profile/pamf...

18.01.2026 20:49 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother’s milk - Nature Communications Here, with metagenomic analyses on longitudinal samples collected from 195 mother-infant pairs, the authors show that the breast milk microbiome contributes to infant gut assembly through bacterial st...

Breast milk isn't just nutrition – it delivers live bacterial strains that colonize the infant gut and persist for months.

Happy to share our new paper, where we used metagenomics to track bacterial strains between 195 mother-infant pairs over the first 6 months of life:

doi.org/10.1038/s414...

18.01.2026 20:35 πŸ‘ 72 πŸ” 23 πŸ’¬ 2 πŸ“Œ 0

Thanks Willem!

06.01.2026 16:24 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I just signed up and read the first of Ran's posts. Excellent stuff, highly recommended.

06.01.2026 08:27 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Indeed - the advantage here (as I write in the post) is that Scholar Labs gives you a link to the text of each paper, which you can read and evaluate. But so far, based on a few weeks of almost daily usage, it hasn't returned any noise.

01.01.2026 17:49 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
Ran’s Substack | Ran Blekhman | Substack My personal Substack. Click to read Ran’s Substack, by Ran Blekhman, a Substack publication. Launched a month ago.

This is my new blog where I write about microbiome research and academic science. Would love to have you subscribe: blekhman.substack.com

01.01.2026 17:07 πŸ‘ 6 πŸ” 0 πŸ’¬ 1 πŸ“Œ 1