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Lee Henry

@henrylabsymbio

Exploring endosymbiosis at Queen Mary University of London. Associate professor. Symbiosis, ecology, evolution, microbiology http://henry-lab.co.uk

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27.05.2025
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Latest posts by Lee Henry @henrylabsymbio

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Associate Senior Lecturer/Assistant Professor in Molecular Microbiology The Department of Biology conducts research and teaching in many subject areas such as ecology, evolutionary biology, organismal biology and molecular biology. A total of approximately 300 people curr

Great opportunity to join Lund University as an Assistant Professor in bacterial molecular biology (open to anyone with up to 7 years of experience post-PhD).

lu.varbi.com/en/what:job/...

06.03.2026 11:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
A phylogenetic tree of insects is shown annotating the presence or absence of a an antimicrobial peptide gene across winged insects

A phylogenetic tree of insects is shown annotating the presence or absence of a an antimicrobial peptide gene across winged insects

Various phylogenetic secondary loss events are mapped to a tree of insects to explain the parsimony calculations necessary to explain the diversity of insect Drosomycin antimicrobial peptide genes

Various phylogenetic secondary loss events are mapped to a tree of insects to explain the parsimony calculations necessary to explain the diversity of insect Drosomycin antimicrobial peptide genes

Antimicrobial peptides (AMPs) are key defence molecules of the innate immune system of plants and animals. Understanding the evolutionary origins of AMPs can help to explain how immune systems acquire novelty and vary in their defensive capabilities. However, AMPs evolve rapidly, and so the origins of similar AMPs across organisms is often unclear. Furthermore, false negatives due to low search sensitivity are common and can hinder confident annotations about true absences. Due to these difficulties, understanding whether similar AMP genes found in diverse organisms represent ancestral molecules or evolutionary novelties has been challenging. In this report, we present evidence of
horizontal gene transfer (HGT) of the antifungal peptide gene Drosomycin across insects. We show that in Diptera, the presence of Drosomycin is restricted to the Melanogaster group and additionally the
distant relative Drosophila busckii. We go on to recover Drosomycin genes in cockroaches (Blattodea), mantises (Mantodea), one katydid (Orthoptera), various beetles (Coleoptera), and a recently acquired
pseudogenized Drosomycin locus in Liposcelis booklice (Psocodea), but no other insects. Explaining this diversity through shared ancestry requires at least 50 independent loss events, or just seven HGT
events. Previous studies have suggested that similar AMPs found across divergent species reflect conservation from a common ancestor, or due to their small size, that they arose via convergent evolution resulting from pathogen-imposed selection. Our findings suggest horizontal gene transfer can be responsible for the presence of some AMP genes found scattered across the tree of life. By presenting a mechanism through which immune systems can acquire novelty, our study also suggests a possible explanation for certain lineage-specific competencies for defence against infectious disease. While loss of AMP genes is common in certain lineages, here we suggest gain of AMPs can occur just as suddenly.

Antimicrobial peptides (AMPs) are key defence molecules of the innate immune system of plants and animals. Understanding the evolutionary origins of AMPs can help to explain how immune systems acquire novelty and vary in their defensive capabilities. However, AMPs evolve rapidly, and so the origins of similar AMPs across organisms is often unclear. Furthermore, false negatives due to low search sensitivity are common and can hinder confident annotations about true absences. Due to these difficulties, understanding whether similar AMP genes found in diverse organisms represent ancestral molecules or evolutionary novelties has been challenging. In this report, we present evidence of horizontal gene transfer (HGT) of the antifungal peptide gene Drosomycin across insects. We show that in Diptera, the presence of Drosomycin is restricted to the Melanogaster group and additionally the distant relative Drosophila busckii. We go on to recover Drosomycin genes in cockroaches (Blattodea), mantises (Mantodea), one katydid (Orthoptera), various beetles (Coleoptera), and a recently acquired pseudogenized Drosomycin locus in Liposcelis booklice (Psocodea), but no other insects. Explaining this diversity through shared ancestry requires at least 50 independent loss events, or just seven HGT events. Previous studies have suggested that similar AMPs found across divergent species reflect conservation from a common ancestor, or due to their small size, that they arose via convergent evolution resulting from pathogen-imposed selection. Our findings suggest horizontal gene transfer can be responsible for the presence of some AMP genes found scattered across the tree of life. By presenting a mechanism through which immune systems can acquire novelty, our study also suggests a possible explanation for certain lineage-specific competencies for defence against infectious disease. While loss of AMP genes is common in certain lineages, here we suggest gain of AMPs can occur just as suddenly.

Pleased to finally share this fun collab that began at #Ento23

@cedricaumont.bsky.social presented & I had seen NCBI annotated some cockroach genomes as "contaminated." Turns out NCBI & I were wrong (much more fun).

Horizontal transfer of an #AntimicrobialPeptide across insects
bit.ly/DrsHGT

1/🧡

06.03.2026 08:22 πŸ‘ 57 πŸ” 22 πŸ’¬ 2 πŸ“Œ 1

Amazing opportunity to join the @hassansalem.bsky.social lab studying symbiosis of leaf beetles!

04.03.2026 12:58 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Join @berasymbionts.bsky.social , @tatsuyanobori.bsky.social and us for a postdoc on the remarkable developmental biology of symbiosis!

Applications are due March 25th πŸͺ²πŸ¦ 

@johninnescentre.bsky.social @thesainsburylab.bsky.social

04.03.2026 11:08 πŸ‘ 30 πŸ” 42 πŸ’¬ 0 πŸ“Œ 2
Details | Working at Bristol | University of Bristol

🚨JOB alert🚨

We have three (yes, THREE) 🌟lectureships🌟 advertised in the School of Biological Sciences, University of Bristol.

Broad remit, including #AnimalBehaviour & #GlobalChangeBiology

⏱️Deadline: 8th March 2026
πŸ™Please circulate widely

😊Come join us!

Full #job details: tinyurl.com/y3us95rc

23.02.2026 18:13 πŸ‘ 63 πŸ” 97 πŸ’¬ 0 πŸ“Œ 0
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A parasitic, parthenogenetic ant with only queens and without workers or males Hamaguchi, Kinomura and colleagues describe an ant species that lacks workers and males and consists exclusively of queens.

πŸ“„ A parasitic, parthenogenetic ant with only queens and without workers or males 🐜

⬇️
www.cell.com/current-biol...

24.02.2026 12:06 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Studying adaptation at the invisible scale | PNAS In order to understand adaptation by natural selection, it is necessary to observe organisms in their natural habitat. For this reason, the field o...

How to study adaptation in organisms that we can’t see, living in environments that we can’t visit? Some thoughts in our perspective piece out today in @pnas.org www.pnas.org/doi/10.1073/... @biology.ox.ac.uk @stuwest.bsky.social

24.02.2026 09:28 πŸ‘ 19 πŸ” 9 πŸ’¬ 1 πŸ“Œ 0
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Entomology technician post in my lab in London (position is for 11 months starting August 2026). The work is about sentience and cognition in a variety of insect species. Thank you for sharing (and applying)! qmul-jobs.tal.net/vx/mobile-0/...

24.02.2026 15:19 πŸ‘ 27 πŸ” 30 πŸ’¬ 0 πŸ“Œ 1

Awesome work Piotr and team! πŸ‘

20.02.2026 09:31 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
The visualization of two bacterial genomes, of 50 and 52kb, representing independent instances of extreme genomic reduction in ancient heritable endosymbionts of planthoppers.

The visualization of two bacterial genomes, of 50 and 52kb, representing independent instances of extreme genomic reduction in ancient heritable endosymbionts of planthoppers.

Our new paper in @natcomms.nature.com is now online-early!

We describe independent evolution of bacterial genomes of only ~50–52 kb β€” the smallest known outside cellular organelles β€” revealing striking convergence toward minimal gene sets.

πŸ”— doi.org/10.1038/s414...

11.02.2026 11:15 πŸ‘ 79 πŸ” 29 πŸ’¬ 5 πŸ“Œ 6

Awesome paper guys! πŸ™ŒπŸΌ

17.02.2026 09:08 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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How specific are heritable symbioses?

And what can we learn from swapping obligate symbionts across host species?

We address this in our latest, led by @inespons.bsky.social & in our collaboration w/ @microbiome.bsky.social 🦠πŸͺ² Out today in @natcomms.nature.com!

1/n
www.nature.com/articles/s41...

16.02.2026 07:24 πŸ‘ 114 πŸ” 70 πŸ’¬ 3 πŸ“Œ 3

Awesome work Ines and Hassan! πŸ™ŒπŸΌ

17.02.2026 09:00 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

We understand a great deal about how and why cooperation evolves, but what about its long-term consequences?

Great to see our new review on this out now in @asn-amnat.bsky.social!

13.02.2026 09:47 πŸ‘ 31 πŸ” 12 πŸ’¬ 0 πŸ“Œ 0
Eusociality has independently evolved in multiple arthropod lineages

Eusociality has independently evolved in multiple arthropod lineages

Eusociality has independently evolved in multiple arthropod lineages

Eusociality has independently evolved in multiple arthropod lineages

Comparative analysis across 5,678 insect species shows that, when you control for phylogenetic bias, eusociality has not evolved at a faster rate in haplodiploid species. www.pnas.org/doi/10.1073/...

12.02.2026 18:41 πŸ‘ 29 πŸ” 20 πŸ’¬ 0 πŸ“Œ 0
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NEW: Registration is now FREE for graduate students and postdocs for the 14th Annual Yosemite Symbiosis workshop. THANKS to the Gordon and Betty Moore Foundation! Space is limited. Learn more and REGISTER here: snri.ucmerced.edu/form/symbios...

08.02.2026 17:29 πŸ‘ 16 πŸ” 13 πŸ’¬ 0 πŸ“Œ 0

@alexdemendoza.bsky.social

30.01.2026 18:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Lecturer in Ecology and Evolution position available in Biology Department at Stanford University. Apply by April 1, 2026. (Photo by Rick Morris)
academicjobsonline.org/ajo/jobs/31606

30.01.2026 05:35 πŸ‘ 21 πŸ” 32 πŸ’¬ 1 πŸ“Œ 0
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Research Group Leader Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...

We are hiring for group leaders again β€” EBI is a great place to start your research group!

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

30.01.2026 09:02 πŸ‘ 66 πŸ” 89 πŸ’¬ 0 πŸ“Œ 2
Uppsala in late autumn

Uppsala in late autumn

Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...

28.01.2026 20:28 πŸ‘ 158 πŸ” 186 πŸ’¬ 1 πŸ“Œ 5
Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont Heritable microbes profoundly influence insect biology, yet the traits they confer often evolve rapidly and differ among closely related symbiont strains. Despite their importance, we lack a clear understanding of how novel traits arise in symbiosis and how this diversity influences host ecology in natural populations. The aphid facultative symbiont Regiella insecticola is ideally suited to this question because of its strong lineage-specific variation in host benefits. By generating 20 high-quality genomes, we found that Regiella ’s evolution is driven largely by gene gains mediated by mobile genetic elements. We identified a plasmid (pRILSR1) that encodes a type IV secretion system and a highly expressed predicted effector that has been convergently acquired by Regiella strains from pea aphids. Notably, only pRILSR1-bearing strains confer protection against the specialist fungal pathogen Pandora neoaphidis , indicating that gains and losses of the plasmid underlie the evolution of this key defensive phenotype. Using a multi-year field study, we further show that the pRILSR1 plasmid is strongly associated with Regiella found in pea aphid populations adapted to specific host plants, driving variation in symbiont-mediated defense across populations. Together, our results show that mobile genetic elements generate key adaptive traits in microbial symbionts and, in doing so, drive phenotypic divergence among host populations. ### Competing Interest Statement The authors have declared no competing interest.

New preprint! Symbionts provide critical functionsβ€”but how do they impact host phenotypes in nature? We show a horizontally transferred plasmid in a heritable symbiont drives divergence in defensive traits across insect populations, revealing how mobile DNA rapidly shapes pathogen resistance. πŸ‘‡

28.01.2026 15:41 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

Cool study @gunizgozeeren.bsky.social @jameslightfoot.bsky.social and team!

22.01.2026 12:07 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Cool findings!

22.01.2026 09:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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My team at @cbitoulouse.bsky.social is recruiting a postdoc #bioinformatics with solid experience in metagenomic analyses.
Interest in evolution, ecology & MGEs is important.
The offer stands until the perfect candidate is found, and it could be you 🫡

πŸ” πŸ™

#microSky #phagesky #UTIsky
@cnrs.fr

15.01.2026 11:19 πŸ‘ 27 πŸ” 55 πŸ’¬ 1 πŸ“Œ 0
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Research Fellow - Department of Microbes, Infection and Microbiomes - 105518 - Grade 7 The post holder will work within the newly established NIHR Health Protection Unit for Public Health Genomics, a partnership between the University of Birmingham and the UK Health Security Agency. You...

Love microbes & omics? 🦠🧬

We’re hiring a Postdoc in Public Health Genomics at @unibirmingham.bsky.social

Work on cutting-edge research with wonderful people! @wvschaik.bsky.social @halllab.bsky.social @pathogenomenick.bsky.social @scalene.bsky.social @alanmcn1.bsky.social

πŸ“… Closes 4th Feb

16.01.2026 15:56 πŸ‘ 7 πŸ” 16 πŸ’¬ 0 πŸ“Œ 1

Congrats and well deserved Toby! πŸ‘

14.01.2026 13:58 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Amazing! Well done @tobykiers.bsky.social πŸ‘

14.01.2026 13:54 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

New preprint out!
How do host regulate ancient symbioses to optimise benefits across environments? Using 🐜, we show hosts actively regulate symbionts, flexibly switching between symbiont-derived and environmental nutrients to thrive under changing diets.
πŸ‘ Well done Phoebe and team!

13.01.2026 16:25 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Research Associate / Postdoctoral Fellow - Honeybee Bacteriophages and Advanced Biotechnology - University of Canterbury | Te Whare Wānanga o Waitaha

We’re looking for a postdoc to join the Hendrickson lab!
The project will involve dissecting the molecular mechanisms of a fascinating mobile element in our honeybee biocontrol phages. Sound like something you would be interested in? Get in touch! Details:
jobs.canterbury.ac.nz/jobdetails/a...

09.01.2026 00:27 πŸ‘ 19 πŸ” 40 πŸ’¬ 0 πŸ“Œ 2

Nice paper JB!

07.01.2026 17:45 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0