Dan Belsky

So much more to do! Data are freely available for research purposes. Applications required to establish data security protocols, etc. Please reach out with questions if you need help getting access.

And now in this database paper, broad evidence for down-regulation of inflammation in adipose tissue www.nature.com/articles/s43...

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study Two years of sustained CR in humans positively affected skeletal muscle quality, and impacted gene expression and splicing profiles of biological pathways known to affected by CR in model organisms. ...

Changes in the muscle transcriptome parallel to mouse CR experiments onlinelibrary.wiley.com/doi/10.1111/...

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial - Nature Aging Using samples and data from the CALERIE study, a human randomized controlled trial of long-term caloric restriction, the authors find that the intervention slows DunedinPACE, a DNA methylation measure...

Slowed pace of aging as measured by the DunedinPACE epigenetic clock, but no effect on the GrimAge, PhenoAge, or first-generation clocks www.nature.com/articles/s43...

Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis Abstract. Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes

Key results include signs of epigenetic changes in the opposite direction from
obesity and smoking academic.oup.com/biomedgeront...

Motivated by these early findings, we generated a range of genomic data from stored blood, muscle, and adipose tissue to test for further signs of slowed biological aging.

A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge - GeroScience Methods to quantify biological aging are emerging as new measurement tools for epidemiology and population science and have been proposed as surrogate measures for healthy lifespan extension in gerosc...

See also link.springer.com/article/10.1...

Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis Abstract. Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow

In early work we found that intervention slowed increases in blood-chemistry indices of biological aging academic.oup.com/biomedgeront...

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. These findings suggest the potential for a substantial advantage for cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits.

www.thelancet.com/journals/lan...

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity AbstractBackground. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for

The trial found large impacts on weight loss and indicators of cardiometabolic health academic.oup.com/biomedgeront...

CALERIE is the first ever RCT of calorie restriction in non-obese healthy human adults calerie.duke.edu

Get the data at agingresearchbiobank.nia.nih.gov

The CALERIE Genomic Data Resource - Nature Aging Ryan and colleagues present multi-tissue, multi-omics, longitudinal datasets from the CALERIE phase 2 randomized controlled trial of caloric restriction in humans, providing a powerful resource for tr...

The CALERIE Genomic Data Resource is up www.nature.com/articles/s43...