Zwartlab NKI

Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations - PubMed In summary, we identify a complex genomic-epigenomic interplay in EC development and progression, altering 3D genome organization to enhance expression of the critical driver ERα.

Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/

Whole genome sequencing of 378 prostate cancer metastases reveals tissue selectivity for mismatch deficiency with potential therapeutic implications - PubMed NCT01855477.

Check out our latest paper! WGS on 378 metastases of patients with prostate cancer. Biggest findings: 1. Non-coding mutations converge on DNA damage repair 2. Coding mutations defer between metastatic sites, with potential implications on systemic therapy selection.
pubmed.ncbi.nlm.nih.gov/40114169/

TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number...

Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story!

www.biorxiv.org/content/10.1...

The emerging regulatory interface between DNA repair and steroid hormone receptors in cancer Human cells potentiate highly diverse functions through tight transcriptional regulation and maintenance of genome integrity. While the DNA damage response (DDR) safeguards the genome, ligand-activate...

What do steroid hormone receptor action and DNA damage repair have in common? Check out our latest review in @cp-trendsmolecmed.bsky.social!

pubmed.ncbi.nlm.nih.gov/39934021/

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Join us for the 2025 Cancer Genetics and Epigenetics GRC in Tuscany, Italy, May 18–23, where global experts will present their latest breakthroughs and discuss the future of cancer research.

Register today: www.grc.org/cancer-genet...

Looking forward visiting @inem-necker.bsky.social and @goffinlab.bsky.social! Great day of talking science and meeting scientists in the beautiful city of Paris; whats not to like? 😁

I'm pleased to announce that the ASCO/Conquer Cancer Foundation Felix Feng Prostate Cancer YIA is now fully endowed and will fund a young prostate cancer investigator every year, in perpetuity. The First Felix Feng YIA recipient will be announced this spring and celebrated at ASCO's annual meeting.

In Memory of Dr. Felix Feng

In Memory of Dr Felix Feng, our beloved friend and a giant in prostate cancer @ericsmall.bsky.social @ucsfcancer.bsky.social

www.sciencedirect.com/science/arti...