Adlung Lab

Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance Nature Metabolism - Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find...

Brown fat (BAT) goes on your nerves? Rather the opposite: Two types of neurons separately regulate glucose tolerance and blood flow / thermogenesis. Cool paper from Lori Zeltser, PhD in Nature Metabolism: www.nature.com/artic... 🧪

Great resource, thanks a lot for compiling! And to students: I was asked about characteristics between mammalian vs. bacterial kinases in my PhD defence, so you better have a look 🤓

Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions - Nature Communications To what extent can large-scale approaches accurately reconstruct classic signaling pathways? Here, authors revisit the EGF pathway using phosphoproteomics and kinase-substrate interactions

Interested in kinase-driven signaling interactions? Check out our (now peer-reviewed) paper together with @savitski-lab.bsky.social on reconstructing signaling networks from phosphoproteomics data and prior knowledge:
➡️ doi.org/10.1038/s414...

Evaluating the analytical performance of direct-to-consumer gut microbiome testing services - Communications Biology Comparative analysis of DTC gut microbiome testing services reveals significant methodological variability, underscoring the need for standardized reference materials and guidelines to ensure reproducibility and reliability in commercial microbiome testing.

Results and health assessments from gut microbiome home-testing kits vary whether they are produced by the same or different manufacturers. The findings, published in Communications Biology, highlight the need for caution when interpreting or acting on test results, according to the authors. 🧪

Thanks to @natrevmicro.nature.com for discussing our work on gut microbiome control of HIV immunodeficiency as research highlight: www.nature.com/artic... 🧪

How do authors want to use AI for review? - EMBO Reports EMBO Reports - A survey of researchers who compared AI-generated scientific reviews with journal-agnostic human peer review reveals that they overwhelmingly prefer using AI as a self-checking tool...

This is such a great and timely survey on author's perception of peer review vs AI scientific review. A collaboration between @reviewcommons.org and @qedscience.bsky.social. The geek in me would have liked to see the distributions in the response scores ;). link.springer.com/article/10.1...

Polystyrene microplastics hamper efferocytosis through accumulating methylglyoxal. Overexpression of glyoxylase-1 rescues the phenotype. Great work by Ana Codo from @mskcancercenter.bsky.social et al. open access in Immunity: www.cell.com/immunit... 🧪

Great review on efferocytosis and metabolic reprogramming in Springer Nature Cell Death & Disease from Karen Cristina Oliveira et al. from São Paulo State University:
www.nature.com/artic... 🧪

Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1

I didn't know about the GEOCODE cohort until I saw this new paper in @natureportfolio.nature.com on machine learning cytokine responses in healthy humans from Claire Liefferinckx et al. (@ulbruxelles.bsky.social)
Very cool!
www.nature.com/articles/s41... 🧪

Sweets from Paris

Was great to have @adeczkowska.bsky.social here, who delivered science & sweets from @aleksdelab.bsky.social of @pasteur.fr. Even more: She pointed out this stimulating essay by Ruslan Medzhitov on the balance of knowledge in immunology: www.nature.com/articles/s41... 🧪 @natrevimmunol.nature.com

Great new paper from the immunodynamics group of Grégoire Altan-Bonnet, whom I admire scientifically, out now in @cp-cell.bsky.social. They show that immunotherapy outcomes are stochastic but Spark T cell abundance predicts responses: www.cell.com/cell/fu... 🧪

And here's the press release from the Weizmann Institute: wis-wander.weizmann.ac.il/life-science... 🧪

New paper out on the role of Extracellular Vesicle (EV) cargo (from different apoptotic cells) on macrophage identity in Schistosomiasis. Christoph from my group and I were glad to make a humble contribution. Out now in the Journal of Extracellular Biology: isevjournals.onlinel... 🧪

I don't like the phrasing of the "bomb", but otherwise I like the idea of engineering macrophages to undergo controlled pyroptosis in the tumor micro-environment: www.cell.com/cell-re... 🧪 out in Cell Reports

Great pieces in the Voices of Cell Systems feat. Julio Saez-Rodriguez and @klingmuelab.bsky.social on the frontiers of systems biology in the next decade: www.cell.com/cell-sy... 🧪
TL;DR: Longitudinal deep molecular profiling and multimodal models for virtual organs and humans.

Epstein files reveal deeper ties to scientists than previously known Latest batch of documents show researchers consulting the financier and sex offender on publications, visas and more.

Newly released files from the investigation of convicted sex offender Jeffrey Epstein reveal that his ties to the scientific community were deeper than previously known

go.nature.com/4tFtHbT

Interesting paper from Kumar et al. (Mayo Clinic) in Cell Metabolism showing that oleic acid exacerbates synovitis through induction of pyroptosis of CD4 T cells. Perilipin-2 knockdown prevented phenotype: www.cell.com/cell-me... 🧪

Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection Nature Microbiology, Published online: 16 February 2026; doi:10.1038/s41564-025-02253-8Human immunodeficiency virus (HIV)-associated gut microbiome dysbiosis correlates with systemic immunodeficiency and opportunistic gut infections. Faecal microbiome transplantation from people living with HIV with high peripheral CD4+ T cell counts improved intestinal immunity and protection against Cryptosporidium parvum in mice.

Out Now! Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection #MicroSky

🚨 New paper out today in Nature Microbiology! During my postdoc we explored how the gut microbiome of people living with HIV impacts immune function and susceptibility to opportunistic infections.

🧵

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Very cool work from my friend Naveed! 👇🏻

So, no, in the paper, we do not zoom in.

Thanks, Damian. Valid question, and definitely something to follow up on (:

Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection Nature Microbiology - Human immunodeficiency virus (HIV)-associated gut microbiome dysbiosis correlates with systemic immunodeficiency and opportunistic gut infections. Faecal microbiome...

🏆 Many thanks to my co-authors Stavros, Melina, Rafael, Jemal and the others, as well as to our fantastic supervisors, Hila & Eran.
ElinavLab @elinav-dkfz.bsky.social @dkfz.bsky.social @uni-hamburg.de

🔗 doi.org/10.1038/s415... 🧪

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🤝 Our findings suggest the gut microbiome serves as a regulatory hub, which is shaped by an immune compromise impacting mucosal immunity and infection susceptibility. Microbiome-targeted interventions may complement current HIV treatment.

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🧹 We then tested clinical relevance using Cryptosporidium parvum, which is an opportunistic pathogen causing severe disease in immunocompromised individuals. Mice receiving FMT from high-CD4 donors showed significantly improved oocyst clearance.

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📊 This effect was robust: independent of mouse strain, gender, single vs repeated FMT, and observed in both germ-free and antibiotic-treated recipients. Even second-generation mouse-to-mouse transfers showed the phenotype.


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➡️ FMT from donors with high CD4+ T cell counts (≥500/µl) induced colonic epithelium-associated CD4+ T cells in recipient mice. FMT from severely immunodeficient donors (<200/µl) failed to induce this response.


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🛡️ B. fragilis has known immunomodulatory functions, including the ability to induce CD4+ T cell-dependent immune responses.
💩🐁 To test causality, we performed faecal microbiome transplantation (FMT) into germ-free and antibiotic-treated mice. The results were striking...
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🦠 There were correlations between HIV-related dysbiosis and systemic immunodeficiency. Specific microbiome alterations tracked with peripheral CD4+ T cell counts, which is a key marker of immune status.
Bacteroides fragilis was associated with high CD4+ T cell counts in untreated individuals.

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